A preform configured to form a carbonated beverage container. The preform includes a finish defining an opening. A body portion of the preform extends from the finish. A bottom portion of the preform is at an end of the preform opposite to the finish. A longitudinal axis of the preform extends through an axial center of the bottom portion. A base layer is included with the body portion and the bottom portion. The base layer has an inner portion with an inner surface at a carbonated product side of the preform. An outer portion of the base layer has an outer surface at an outer bottle side of the preform. A passive CO2 barrier layer is between the inner portion and the outer portion of the base layer. The passive CO2 barrier layer extends along the body portion to the bottom portion, and across the bottom portion. The passive CO2 barrier layer is arranged closer to the inner surface than the outer surface to increase the shelf-life of carbonated products.

The present invention provides a method of producing a microneedle array with excellent mountability on a container and excellent handleability such as puncture or disposal, a microneedle array, and a microneedle array unit.

Provided are a method of producing a microneedle array including a step of placing a support member which includes a disk portion having a through-hole and a columnar portion formed on a first surface of the disk portion, on a pattern surface of a mold having needle-like depressions, a step of supplying a base material liquid from a side of the first surface of the disk portion and filling the needle-like depressions with the base material liquid, and a drying step of drying the base material liquid to integrally mold a base material layer and the support member; the produced microneedle array; and a microneedle array unit including the microneedle array and a container.

The present invention relates to a melt extrusion process for preparing a solid dispersion comprising a pharmaceutically active ingredient, a polymeric binder, and, optionally, one or more auxiliary agents, comprising a) in a batch-wise operation, placing a pre-determined amount of the polymeric binder, a pre-determined amount of the active ingredient, and, optionally, a pre-determined amount of the auxiliary agent(s) in a melting vessel; melting the polymeric binder with agitation to disperse the active ingredient in the polymeric binder to obtain a molten pre-dispersion; b) feeding the pre-dispersion into an extruder to homogenize the pre-dispersion and release a melt through a die; and c) allowing the melt to solidify.

The present invention relates to process for preparing a drug delivery composition comprising the steps of a) preparing a masterbatch comprising a drug and a first polymer by (i) extruding the first polymer, wherein said first polymer has a melting temperature below 140 C.; and (ii) introducing the drug during extrusion of the first polymer, with a drug content between 0.1% and 90%, based on the total weight of the masterbatch; and b) introducing the masterbatch in a polymer-based matrix during production of the drug delivery composition, wherein step a) is performed at a temperature at which the first polymer is in a partially or totally molten state, and step b) is performed at a temperature at which both the first polymer and at least a polymer of the polymer-based matrix are in a partially or totally molten state.

Provided is a method of producing a layered article by which a sufficient production speed can be achieved, and preferably, a variation in fusion strength can be suppressed and hence a variation in product quality can be reduced. The method of producing a layered article of the present invention includes fusing at least part of a single-layer body or a laminate including at least one layer including a non-woven fabric of fiber having a fiber diameter of 100 m or less through ultrasonic welding.

Provided is a method of producing a layered article by which a sufficient production speed can be achieved, and preferably, a variation in fusion strength can be suppressed and hence a variation in product quality can be reduced. The method of producing a layered article of the present invention includes fusing at least part of a single-layer body or a laminate including at least one layer including a non-woven fabric of fiber having a fiber diameter of 100 m or less through ultrasonic welding.

A microprotrusion device (1A) according to the present invention includes a needle-like and hollow first protrusion portion (3) that is formed so as to protrude from one surface (2a) of a substrate sheet (2) and a hollow second protrusion portion (4) that is formed so as to protrude from a vicinity of the first protrusion portion (3) on the one surface (2a) of the substrate sheet (2) and has a protrusion height lower than that of the first protrusion portion (3). The first protrusion portion (3) has an opening at its tip end portion, and a hollow portion (30) of the first protrusion portion (3) is in communication with the outside via the opening portion (31). The opening portion (31) is formed at the tip end of the first protrusion portion (3).

The present disclosure provides a fully degradable Polyglycolic acid (PGA) composite packaging material comprises, by weight part, the following: PGA, polycaprolactone, poly(L-lactide--caprolactone), anti-blocking agent, slipping agent, flexibilizer, waterproofing agent, chitosan, reinforced fibers and the like. The present disclosure further provides a preparation method of the fully degradable modified polyglycolic acid composite packaging materials. The present disclosure has the following advantages. The packaging material of the present disclosure has good microbial degradation and hydrolysis. With complete biodegradation, it would result in end-products, water and carbon dioxide, which are environmentally friendly, non-toxic and pose no threat to human- and animal-health. The packaging material of the present disclosure has good mechanical properties, and can fully meet various application requirements of packaging materials. Inexpensive and environmental pollution-free fillers can be added without influence on mechanical properties. The cost can be effectively reduced. The preparation process is simple.

Provided is a molded article comprising an aliphatic polyester. The aliphatic polyester is at least one selected from the group consisting of polyglycolic acid and a copolymer of a glycolic acid monomer and a monomer other than the glycolic acid monomer. The molded article has a uniaxial compressive strength at a temperature of 23 C. of greater than 250 MPa and not greater than 350 MPa.

In one embodiment, a method to form a downhole element is disclosed, including weaving a continuous glass filament and a continuous degradable thermoplastic filament to form a commingled glass fiber. In another embodiment, a commingled glass fiber is disclosed, including a continuous glass filament, and a continuous degradable thermoplastic filament interwoven with the continuous glass filament. In another embodiment, a downhole element is disclosed, including a commingled glass fiber. The commingled glass fiber includes a continuous glass filament, and a continuous degradable thermoplastic filament interwoven with the continuous glass filament.