A method and device for fabricating vascular networks in for tissue engineering. The vascular network is embedded in a porous scaffold and is created from a sacrificial wax template, according to one embodiment. A extrusion-based three dimensional printer is used to create the template, wherein the printer utilizes an extruder incorporating a mixer to maintain the consistency of the extrudate.

An article having an embossed seal includes at least two webs, and an embossed seal joining a portion of the at least two webs, the seal including co-registered concentric discrete extended elements formed in the at least two webs, the discrete extended elements having open proximal ends.

An article having an embossed seal includes at least two webs, and an embossed seal joining a portion of the at least two webs, the seal including co-registered concentric discrete extended elements formed in the at least two webs, the discrete extended elements having open proximal ends.

The present invention relates to an integrally blow-moulded bag-in-container (2) having an integrally blow-moulded bag-in-container wherein the same polymer is in contact on either side of the interface between the inner (11) and outer layers (12). It also concerns a preform (1, 1) for blow-moulding a bag-in-container, having an inner layer and an outer layer, wherein the preform forms a two-layer container upon blow-moulding, and wherein the thus obtained inner layer of the container releases from the thus obtained outer layer upon introduction of a gas at a point of interface between the two layers. The inner and outer layers are of the same material.

Small-, medium-, and large-caliber combustible cartridge cases and propellant combustible containers that are manufactured using reactive injection molding of azido polymers. An injection process for a single propellant combustible charge including the steps of: providing a quantity of azido bearing polymer; providing a quantity of curing agent; optionally providing a quantity of chemical blowing agent; optionally providing a quantity of fibers; optionally providing a quantity of additives and catalysts; and providing a mold defining a male cavity, a female cavity, and an injection port. The injection process further includes mixing together the azido bearing polymer, the curing agent, the optional chemical blowing agent, the optional fibers, the optional additives and catalysts, and injecting the resulting mixture into the mold.

The present invention relates to process for preparing a drug delivery composition comprising the steps of a) preparing a masterbatch comprising a drug and a first polymer by (i) extruding the first polymer, wherein said first polymer has a melting temperature below 140 C.; and (ii) introducing the drug during extrusion of the first polymer, with a drug content between 0.1% and 90%, based on the total weight of the masterbatch; and b) introducing the masterbatch in a polymer-based matrix during production of the drug delivery composition, wherein step a) is performed at a temperature at which the first polymer is in a partially or totally molten state, and step b) is performed at a temperature at which both the first polymer and at least a polymer of the polymer-based matrix are in a partially or totally molten state.

A method for 3D printing a patient-specific bone implant having variable density, in various aspects, comprises: (1) providing a thermoplastic polymer composition comprising: (A) between about 20% and about 50% bioactive agent by weight; (B) between about 0.5% and about 10% chemical foaming agent by weight; and (C) balance structural polymer by weight; (2) receiving, by computing hardware, a scan of a bone, the scan comprising at least a 3D image of the bone and radiodensity data for the bone; and (3) causing, by the computing hardware, a 3D printer to form the patient-specific bone implant from the 3D image using the thermoplastic polymer by modifying a 3D printing temperature of the 3D printer during printing of the patient-specific bone implant such that each portion of the patient-specific bone implant is produced at a temperature that corresponds to a desired density defined by the radiodensity data for the bone.

An integrally blow-moulded bag-in-container has as integrally blow-moulded bag-in-container wherein the same polymer is in contact on either side of the interface between the inner and outer layers. A preform for blow-moulding a bag-in-container has an inner layer and an outer layer, wherein the preform forms a two-layer container upon blow-moulding, and wherein the thus obtained inner layer of the container releases from the thus obtained outer layer upon introduction of a gas at a point of interface between the two layers. The inner and outer layers are of the same material.

A masterbatch may be blended with virgin polymer to add desired color or other properties to the virgin polymer prior to further processing. Methods and processes for producing an antimicrobial and/or antiviral polymeric masterbatch that may be used to add antimicrobial, antiviral and/or antifungal properties to a virgin polymer without significantly degrading the properties of the virgin polymer. The masterbatch may be extruded into pellets or formed into other particles for subsequent blending with the virgin polymer to add antimicrobial and antiviral properties to the polymeric materials. The method includes a heat treatment after compounding the base polymer with the antimicrobial, antiviral and/or antifungal are compounded together. The heat treatment comprises heating the masterbatch blend to a temperature between the glass transition temperature and the melting point of the base polymer.

Provided is a molded article comprising an aliphatic polyester. The aliphatic polyester is at least one selected from the group consisting of polyglycolic acid and a copolymer of a glycolic acid monomer and a monomer other than the glycolic acid monomer. The molded article has a uniaxial compressive strength at a temperature of 23 C. of greater than 250 MPa and not greater than 350 MPa.