The present invention provides for a removable second stage biocompatible substrate filter that includes biocompatible implant material configured to trap second stage operative particulate matter that may include at least one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. The second stage biocompatible substrate filter may be configured to combine with bone fragments captured from irrigation fluid by a first stage filter and may be configured to be operable with a reaming and collection device.

This invention relates to a process through which intravenous fluids, blood, or artificial blood containing high-levels of mechanically-injected dissolved oxygen can be used to maintain appropriate oxygen levels in the venous blood and thereby provide short-term oxygenation support for compromised or trauma patients. In one aspect, there is provided a system and process for oxygenating a biological fluid for use in a compromised or a trauma subject in need of oxygenation support to maintain appropriate oxygen levels in the subject, the process comprising: supplying oxygen gas from an oxygen source; and dissolving an amount of the supplied oxygen into a biological fluid to obtain an oxygen enriched biological fluid.

The invention is directed to a catheter-like system which dwells temporarily or even continuously in the body of a patient and which serves for the closed delivery and/or discharge of odour-intensive substances, wherein the release of foul-smelling substances is reduced to the greatest possible extent by the system wall having a multi-layer structure that incorporates a proportion of barrier materials, and an odour-neutral decompression of gaseous fractions arising in the body and discharged into the system is ensured. The system comprises in particular a structure like a tubular film, by which an internal space to be reached in the body is connected to a container, arranged outside the body, for receiving the respective substances that are to be delivered and/or discharged. At the end positioned inside the body, the tube structure is provided with a retaining and/or sealing balloon element, which secures the system in the body. All of the film-based constituent parts of the system that are arranged outside the body, including the film-like delivering and/or discharging tube structure and the container preferably configured in the form of a bag, incorporate at least one barrier-producing layer of ethylene vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC) and/or polyamide (PA), which is combined with at least one carrier layer made of a robust, mechanically loadable, preferably elastic material, for example polyurethane (PUR). The system moreover ensures a continuous decompression of gaseous constituents from the internal space of the system, by a degassing device which is arranged in a particular manner relative to the delivering and/or discharging lumen and by which the adsorbing or filtering, degassing unit is protected against direct exposure to the substances that are to be delivered and/or discharged.

The invention is directed to a catheter-like system which dwells temporarily or even continuously in the body of a patient and which serves for the closed delivery and/or discharge of odour-intensive substances, wherein the release of foul-smelling substances is reduced to the greatest possible extent by the system wall having a multi-layer structure that incorporates a proportion of barrier materials, and an odour-neutral decompression of gaseous fractions arising in the body and discharged into the system is ensured. The system comprises in particular a structure like a tubular film, by which an internal space to be reached in the body is connected to a container, arranged outside the body, for receiving the respective substances that are to be delivered and/or discharged. At the end positioned inside the body, the tube structure is provided with a retaining and/or sealing balloon element, which secures the system in the body. All of the film-based constituent parts of the system that are arranged outside the body, including the film-like delivering and/or discharging tube structure and the container preferably configured in the form of a bag, incorporate at least one barrier-producing layer of ethylene vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC) and/or polyamide (PA), which is combined with at least one carrier layer made of a robust, mechanically loadable, preferably elastic material, for example polyurethane (PUR). The system moreover ensures a continuous decompression of gaseous constituents from the internal space of the system, by a degassing device which is arranged in a particular manner relative to the delivering and/or discharging lumen and by which the adsorbing or filtering, degassing unit is protected against direct exposure to the substances that are to be delivered and/or discharged.

A system includes a respiratory device, a mask, a microphone, a speaker, and a control system. The respiratory device is configured to supply pressurized air. The mask is coupled to the respiratory device and configured to engage a user during a sleep session to aid in directing the supplied pressurized air to the user. The microphone is configured to generate audio data. The speaker is configured to emit sound. The control system is configured to analyze the audio data to determine if noise associated with air leaking from the mask is occurring. Responsive to (i) the analysis resulting in a determination that noise associated with air leaking from the mask is occurring, (ii) the respiratory device determining that air is leaking from the mask, or (iii) both, the speaker is caused to emit the sound to aid in masking the noise associated with the air leaking from the mask.

A system includes a respiratory device, a mask, a microphone, a speaker, and a control system. The respiratory device is configured to supply pressurized air. The mask is coupled to the respiratory device and configured to engage a user during a sleep session to aid in directing the supplied pressurized air to the user. The microphone is configured to generate audio data. The speaker is configured to emit sound. The control system is configured to analyze the audio data to determine if noise associated with air leaking from the mask is occurring. Responsive to (i) the analysis resulting in a determination that noise associated with air leaking from the mask is occurring, (ii) the respiratory device determining that air is leaking from the mask, or (iii) both, the speaker is caused to emit the sound to aid in masking the noise associated with the air leaking from the mask.

A patient interface may include a plenum chamber pressurisable to a therapeutic pressure, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, a positioning and stabilising structure to provide a force to hold the seal-forming structure in a therapeutically effective position on the patient's head, and a vent structure to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient, wherein the patient interface is configured to leave the patient's mouth uncovered during therapy, wherein the seal-forming structure comprises two lateral support regions, each located at a lateralmost side of the seal-forming structure, and a medial region positioned between the lateral support regions, the hole passing through the medial region, and wherein the lateral support regions are thicker than the medial region.

A patient interface may include a plenum chamber pressurisable to a therapeutic pressure, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, a positioning and stabilising structure to provide a force to hold the seal-forming structure in a therapeutically effective position on the patient's head, and a vent structure to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient, wherein the patient interface is configured to leave the patient's mouth uncovered during therapy, wherein the seal-forming structure comprises two lateral support regions, each located at a lateralmost side of the seal-forming structure, and a medial region positioned between the lateral support regions, the hole passing through the medial region, and wherein the lateral support regions are thicker than the medial region.

A system for applying a lavage fluid to a surface, the system having a body configured to house a lavage fluid and at least two interchangeable application members configured to be in fluid communication with the body, wherein the at least two interchangeable application members includes a first application member and a second application member, the first application member being configured to dispense the lavage fluid with a first fluid flow force and/or first fluid flow pattern, and the second application member being configured to dispense the lavage fluid with a second fluid flow force and/or second fluid flow pattern that is different from the first fluid flow force and/or fluid flow pattern, respectively.

A system for applying a lavage fluid to a surface, the system having a body configured to house a lavage fluid and at least two interchangeable application members configured to be in fluid communication with the body, wherein the at least two interchangeable application members includes a first application member and a second application member, the first application member being configured to dispense the lavage fluid with a first fluid flow force and/or first fluid flow pattern, and the second application member being configured to dispense the lavage fluid with a second fluid flow force and/or second fluid flow pattern that is different from the first fluid flow force and/or fluid flow pattern, respectively.