A method for making a biomaterial with a target property, the method comprising: obtaining a precursor biomaterial in a precursor biomaterial vessel, and a biomaterial vessel for compacting the precursor biomaterial therein, wherein a relative reduction in a given dimension of the precursor biomaterial in the precursor biomaterial vessel relative to the given dimension in the formed biomaterial in the biomaterial vessel (compaction factor) is based on the target property of the biomaterial and a change in the property of the biomaterial with the compaction factor.

A formulation usable in additive manufacturing of a three-dimensional object is provided. The formulation comprises one or more monofunctional curable material(s); one or more hydrophilic multifunctional curable material(s); and one or more water-miscible non-curable material(s), such that a total amount of the curable materials is 20% or less, by weight, and a weight ratio of a total weight of the monofunctional curable material(s) and a total weight of the hydrophilic multifunctional curable material(s) ranges from 1:1 to 10:1. The formulation features, when hardened, properties of a weak and flowable gel. Additive manufacturing processes utilizing the formulation as a support material formulation are also provided.

A polymer composition for producing gel extruded articles is described. The polymer composition contains polyethylene particles combined with a plasticizer and an acid scavenger. In accordance with the present disclosure, the acid scavenger is an inorganic compound that is insoluble in the plasticizer and/or any extractions solvents used during the process. In one embodiment, the acid scavenger is a magnesium aluminum hydroxide carbonate.

The present disclosure provides methods for freeform extrusion-based additive manufacturing via a robotic arm. In specific aspects, methods are particularly provided for minimally invasive, intracorporeal three-dimensional printing of biocompatible materials. An end effector of a robotic arm includes a sharp member and a reservoir filled with a printing material. The provided method may include piercing a substrate with the sharp member. A bulb or microbolus of material may be extruded beneath the substrate surface to act as an anchor. The end effector may be manipulated to extrude biomaterial along a printing path. Periodically along the printing path, the sharp member is used to pierce the substrate surface create additional respective anchors. In some instances, the method may terminate after extruding material to form a single layer construct. In other instances, the method includes forming one or more layers on top of the initial base layer anchored to the substrate.

Provided is a method of shaping a composite blade made of a composite material by curing prepreg in which reinforcing fibers are impregnated with resin. A foaming agent disposed in an internal space of the composite blade contains a plurality of foaming bodies and foaming agent resin. The foaming bodies foam by being heated. The foaming agent resin cures by being heated. The foaming bodies include low-temperature side foaming bodies and high-temperature side foaming bodies. The low-temperature side foaming bodies foam in a low temperature range during a curing step. The high-temperature side foaming bodies foam in a high temperature range corresponding to temperatures higher than the low temperature range during the curing step.

An outsole component for use in an article of footwear is manufactured using a molding process that incorporates a second polymeric material with a film component including a first layer formed of a polymeric hydrogel material. The first layer forms the external or ground-facing layer of the outsole. Methods of manufacturing the outsole component, as well as articles of footwear including outsole component and methods of manufacturing such articles of footwear are also described.

A system and method are provided for fabricating 3D structures from biomaterial. The system includes a printer assembly having a dual-arm assembly including an upper arm, and a lower arm connected by an elbow joint to the upper arm. A disposable barrier encloses a printing surface from an external environment and from components of the printer assembly. The upper arm and lower arm are inserted into an inlet of the barrier, so as to be isolated from the print surface. The lower arm is provided with an extruding system, and the extruding system includes an actuator-driven syringe configured to deposit biomaterial on the print surface. The biomaterial is deposited on the print surface to carry out 3D fabrication in an aseptic environment.

A method of system of forming a biopolymer hydrogel structure includes a mold loaded with a cation. At least a portion of the surface of the mold is exposed to a solution comprising a gellable polymer such as alginate. An electric potential is applied to the mold so that the cation therein and the gellable polymer migrate via electrophoresis toward the surface portion, thereby interacting and forming a hydrogel structure adjacent to the surface portion.

A system and method for additive manufacturing of three-dimensional structures, including three-dimensional cellular structures, are provided. The system comprises at least one print head for receiving and dispensing materials, the materials comprising a sheath fluid and a hydrogel, the print head comprising an orifice for dispensing the materials, microfluidic channels for receiving and directing the materials, fluidic switches corresponding to one of the microfluidic channels in the print head and configured to allow or disallow fluid flow in the microfluidic channels; a receiving surface for receiving a first layer of the materials dispensed from the orifice; a positioning unit for positioning the orifice of the print head in three dimensional space; and a dispensing means for dispensing the materials from the orifice of the print head.

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.