Extruded molds and methods for manufacturing composite structures using the extruded molds are disclosed. The molds may include recessed or raised longitudinal features to impart a corresponding shape to the molded composite structures. The composite structures may be panels used to construct cargo vehicles, for example.

A photoinitiated polymerizable composition for 3D printing, the polymerizable composition comprising a nanogel component that comprises nanogel particles, wherein the nanogel particles comprise a copolymer with polymerizable reactive groups suitable for reacting with each other or a reactive diluent monomer, a reactive oligomer, a resin, or a combination thereof that is present in the polymerizable composition upon photoinitiation, wherein the nanogel component has a glass transition temperature that is in a range of about −50 C and about 20 C and an average molecular weight that is in a range of about 10 kg/mol and about 100 kg/mol, and wherein the nanoparticles have an average hydrodynamic radius that is in a range of 1 nm to about 5 nm.

An automated production line for the production of ophthalmic lenses comprises:

a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module

a production line back end (2) comprising:

a treatment module (20),

an inspection module (21),

wherein the production line has the easy adaptability of curing times and temperatures, and in the capability of using different treatment liquids and treatment times in the extraction module to achieve the product flexibility.

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis.

An implant device includes a polymer tube including an enclosed inner space, and a mixture of a hydrogel and a plurality of nanoparticles within the enclosed inner space. Each of the plurality of nanoparticles includes a shell, payload within the shell, and one or more photothermal agents on a surface of the shell. A wall of the polymer tube includes one or more layers of nanoporous polymer sheets including a plurality of pores. The dimension of the nanoparticles is greater than the dimension of the pores, and the dimension of the payload is smaller than the dimension of the pores.

A contact lens manufacturing method for removing a contact lens from a pair of molds, the contact lens being produced by polymerizing a monomer included in the pair of molds which are obtained by assembling a lower mold for forming a front curve of the contact lens and an upper mold for forming a base curve of the contact lens, the method including: (A) a first peeling step to peel the contact lens from the lens formation surface of the upper mold; (B) a separation step to separate the contact lens from the lens formation surface of the upper mold; (C) a second peeling step to peel the contact lens whose periphery sticks to the lens formation surface of the lower mold; and (D) a third peeling step to peel the contact lens, whose periphery has been peeled, from the lens formation surface of the lower mold.

The invention is directed to an embedded hydrogel contact lens, which comprises an insert sandwiched between two layers of hydrogel materials and can be produced according to a cast molding method including the procedures involving two females halves (FC1 and FC2) and two male halves (BC1 and BC2) and three consequential molding steps involving three molding assemblies: the 1st one formed between FC1 and BC1 for molding an insert; the 2.sup.nd one formed between FC1 and BC2 for molding a lens precursor having the molded insert embedded in a layer of a hydrogel material in a way that the front surface of the molded insert merges with the convex surface of the lens precursor; and the 3rd one formed between FC2 and BC2 for molding an embedded hydrogel contact of the invention.

A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

A method of producing a plurality of parts includes placing a sol mixture into a cavity of a tool, optionally placing a metal foil over a top of the cavity and placing a graphite gasket over the metal foil, and securing the tool with the sol mixture to form a tooling capsule. Tooling capsules are placed within a conveyor system and are heated until the solvent of the sol mixture reaches at least supercritical conditions of the solvent. Pressure is released within each of the tooling capsules after the supercritical conditions are reached, and then the tooling capsules are cooled to approximately room temperature. The parts are removed from the tooling capsules, and the method is continuous.