The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprising the steps of formulating a lens formulation by dissolving/blending all polymerizable components in a mixture a hydrophobic acrylic monomer as a reactive diluent and an organic solvent as a non-reactive diluent at a weight ratio of least 0.24 (reactive diluent over the sum of reactive and non-reactive solvents) per gram of the polymerizable composition and using a relatively low ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.

A formulation usable in additive manufacturing of a three-dimensional object is provided. The formulation comprises one or more monofunctional curable material(s); one or more hydrophilic multifunctional curable material(s); and one or more water-miscible non-curable material(s), such that a total amount of the curable materials is 20% or less, by weight, and a weight ratio of a total weight of the monofunctional curable material(s) and a total weight of the hydrophilic multifunctional curable material(s) ranges from 1:1 to 10:1. The formulation features, when hardened, properties of a weak and flowable gel. Additive manufacturing processes utilizing the formulation as a support material formulation are also provided.

There is provided a polyolefin resin foam sheet having a plurality of cells which is formed by foaming a polyolefin resin, wherein, in the polyolefin resin foam sheet, the average cell sizes and the maximum cell sizes in the MD direction and the TD direction are each a predetermined value, and a ratio [TD strength at break/MD average cell size] and a ratio [MD strength at break/TD average cell size] are both 80 kPa/μm or more.

A method of manufacturing a colored contact lens including the steps of providing a transparent contact lens having a pupil section and an iris section, the iris section surrounding the pupil section and applying a colorant to the surface of the contact lens. The colorant is applied to the contact lens as an amorphous pattern and covers an effective amount of the iris section of the same. The amorphous pattern provides a lens capable of changing the apparent color of the iris of a person wearing the lens while imparting a very natural appearance.

A method (2) of producing a radiometric physical phantom of a biological organism to be irradiated or already irradiated having at least two volumes of appreciably different biological tissues comprises a step (6) of determining a radiological three-dimensional model on the basis of anatomical three-dimensional image(s) of the organism, a step (10) of producing a material framework of the phantom with the aid of a 3D printer, and a step (16) of filling the enclosures of the framework with gels. The radiological three-dimensional model groups together into radiological organs the mutually adjacent tissues having chemical compositions and densities which are similar. Each radiological organ is characterized geometrically by a radiological volume as sum of the volumes of the grouped tissues, and radiologically by a radiological class identifying the span of the chemical compositions and densities which are similar of the grouped tissues. A physical phantom manufactured by the method of production and a system for implementing the method of production. A method of experimentally determining the distribution of the doses of radiation on the phantom produced and a system for implementing the method of experimental determination.

Provided are an apparatus and a method of controlling a stiffness of a soft material hardened from a liquid state having viscosity into a solid state. The apparatus of controlling a stiffness of a soft material includes: a soft material accommodating means including a chamber corresponding to a space in which the soft material having fluidity before being hardened is accommodated and a wall structure surrounding the chamber; and a stimulus means applying a stimulus to the soft material to generate a flow in the soft material, wherein a flow is applied to the soft material to control the stiffness in the soft material and control stiffnesses to be different from each other in each region of the soft material.

Provided are a hydrogel composition with high viscoelasticity and a bioink composition including the hydrogel composition. The hydrogel composition according to an embodiment is composed of natural biocompatible substances and thus is not toxic, but has high viscosity, resulting in high mechanical stability or long persistence. Thus, the hydrogel composition may be usefully utilized as a bioink composition for bioprinting, a support in tissue engineering, or a soft tissue filler.

A molded contact lens comprising a stiffer optic zone relative to the peripheral zone of the contact lens provides an optical element for correcting astigmatism without the need for or substantially minimizing the need for the correction of rotational misalignment. The higher elastic modulus optic zone vaults over the cornea thereby allowing a tear lens to form. The tear lens follows or assumes the shape of the back surface of the contact lens. The combination of the tear lens and the optical zone provide an optical element for correction of refractive error.

The present disclosure discloses a silica gel vibrating diaphragm and a method for fabricating the same. The method comprises: forming a composite material belt by using two layers of a base material and liquid silica gel in a calendering manner, wherein the liquid silica gel is between the two layers of the base material; wholly hot-press molding the composite material belt by a vibrating diaphragm die holder, a temperature of the hot-press molding being higher than a vulcanization temperature of the liquid silica gel; removing the two layers of the base material to obtain a whole sheet of silica gel vibrating diaphragm; and blanking the whole sheet of silica gel vibrating diaphragm that has been removed of the two layers of the base material to fabricate a required silica gel vibrating diaphragm. As compared with conventional solutions, the technical solution of the present disclosure has the advantages of simple molding manner, low cost, various styles of the vibrating diaphragm, and small thickness of the vibrating diaphragm.