A tortuous path filter for filtering reconstituted plasma, the filter comprising at least two layers of fibers, single-layer filters, or beads, wherein the filter lacks or substantially lacks pores defining a lumen, said lumen having a diameter of larger than (100) microns along a straight path through the filter. The invention provides devices including a tortuous path filter, and methods for producing transfusion-ready plasma comprising: (a) reconstituting dried plasma to produce reconstituted plasma; and (b) passing said reconstituted plasma through the tortuous path filter to produce transfusion-ready plasma.

A blood reintroduction system can include a canister having a chamber configured to collect blood. A system may include an inlet configured to fluidically connect the chamber to a first tubing in fluid communication with an aspiration catheter. A system may include a first filter within the chamber, wherein the first filter is configured to separate blood from thrombus. A system may include a second filter downstream of the first filter, wherein the second filter is configured to separate blood from thrombus. A system may include a second tubing connected to an outlet of the chamber, wherein the second tubing is configured to reintroduce filtered blood from the chamber to a patient's vasculature.

A blood reintroduction system may include a canister configured to collect blood. The system may include an inlet configured to be fluidly connected to a first tubing in fluid communication with an aspiration system configured to apply aspiration to a vasculature of a patient. The system may include a first outlet configured to be fluidly connected to a second tubing in fluid communication with an aspiration pump. The system may include a second outlet configured to interact with a blood reintroduction device, wherein the blood reintroduction device is configured to withdraw the blood collected inside the canister. The system may include a filter positioned inside a flow path leading to the second outlet.

A CRRT apparatus comprising a control unit configured to execute a flow-rate setup procedure by receiving a patient prescription comprising clinical prescription parameters, by allowing entry of a set value for a prescribed dialysis dose (D.sub.set) to be delivered, and of a target value for a parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, and by determining operating parameters calculating a set value of relevant fluid flow rates including one or more of a fluid flow rate (Q.sub.cit) through the anticoagulant infusion line, a fluid flow rate (Q.sub.PBP) through the PBP infusion line, a fluid flow rate (Q.sub.rep.pre) through the pre-dilution infusion line, a fluid flow rate (Q.sub.rep.post) through the post-dilution infusion line, a fluid flow rate (Q.sub.HCO3) through the post-dilution bicarbonate infusion line, a fluid flow rate (Q.sub.ca) through the ion balancing infusion line, a blood fluid flow rate (Q.sub.b) through the extracorporeal blood circuit, a fluid flow rate (Q.sub.dial) through the dialysis liquid supply line, and a fluid flow rate (Q.sub.eff) through the effluent fluid line, wherein calculating the set value of the fluid flow rates is based at least on the set value of the prescribed dialysis dose (D.sub.set) and on the target value for the parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood.

Methods for aspiration to remove thrombus/clot material using a system configured to remove, filter and return clot. These methods allow the removal of clot material using a fluidically-driven aspiration device when attached to an aspiration catheter and proximate to obstructive clot material. A fluidic actuator drives an aspirator, which may be automatically controlled to apply a vacuum in a pattern to enhance clot removal and collection from the body as well as improve blood return using the same closed system. The fluidic actuator may direct the aspirated blood through a filter and deaerator to allow the filtered blood to be returned to the patient.

Devices for monitoring cancerous cells in blood of a patient that are preloaded with a marker and a magnetic agent and removing them are provided. The device comprises a tray onto which blood withdrawn from the patient flows before returned to the patient; a magnet placed at a distance from the tray so that the blood on the tray is within a magnetic field of the magnet and the cancerous cells that are preloaded with the magnetic agent are forced to move from the blood on the tray towards the magnet. A detector configured to detect the marker in the cancerous cells in the blood on the tray is provided as well and a filter that is placed between the tray and the magnet so as to capture the cancerous cells that are forced to move towards the magnet and remove them from the blood of the patient.

Disclosed is a blood oxygenator. The blood oxygenator includes a blood inlet chamber, and a housing. A hollow cavity is arranged in the housing, and includes a heat exchange zone and a gas exchange zone. Multiple heat exchange filaments are arranged in the heat exchange zone. Multiple hollow fibrous membrane fibers are arranged in the gas exchange zone. The blood inlet chamber includes an inverted conical side wall and an end surface hermetically connected to an opening at one end of the inverted conical side wall, an opening at the other end of the inverted conical side wall is hermetically connected to one end of the housing, and the other end of the housing is hermetically connected with a cover body. The cover body is provided with a blood outlet, and the end surface is provided with a spiral liquid inlet pipe coaxial with the blood inlet chamber.

Circulating cell clusters found in subjects with cancer, autoimmune conditions, infections, or other diseases, can be trapped or disrupted by filtering them with an intra- or extracorporeal device and, in some cases, exposing them to a substance, such as enzyme, that reduces intercellular adhesion.

A supply port is provided in a dialysate supply passage and a discharge port is provided in a dialysate discharge passage. A supply passage is branched on an upstream side of a blood pump in the arterial passage, and a venous passage connection part (branch passage) is provided in the supply passage to which a venous passage can be connected. When priming, with the supply passage connected to the supply port, the arterial passage to the discharge port, and the venous passage to the branch passage of the supply passage, respectively, the dialysate supply device and the blood pump are actuated to simultaneously cause dialysate to flow through the arterial passage and the venous passage to prime the blood circulation passage including a blood purifier and a blood circuit.

Devices and methods for treating patients with respiratory distress syndrome, hypoxemia and hypercapnia. The device is a thermomagnetic inhaler includes two compressed gas sources, the first of which is a source of compressed helium, the second of oxygen, each of the compressed gas sources is sequentially connected by means of sealed tubes to filters, safety valves and adjustable valves, which are connected to a mixer, which is sequentially connected by means of sealed tubes to a heater, a magnetic element, a check valve and a face mask, wherein the magnetic element consists of a hollow magnetic circuit and permanent magnets, flow sensors are connected to sealed tubes between the adjustable valves and the mixer, oxygen and pressure sensors are connected to a sealed tube between the mixer and the heater, adjustable valves, flow sensors, oxygen sensor, pressure sensor and heater are connected to a control device.