A method for electrochemically filtering a bodily fluid in the treatment of a disease includes a pump to circulate the fluid through a collection container and an electromagnetic charging system. One of the cathode and anode leads is connected to a collection plate while the other of the cathode and anode leads is connected a patient to be treated. Inlet and outlet catheters are connected to patient to be treated. A predetermined voltage is applied across the anode lead and the cathode lead from a DC power supply, wherein circulating fluid from the patient passes through the collection container for removal of charged biological materials onto the collection plate. The fluid is returned back to the patient by the pump system.

The present invention relates to a method of identifying a filter, wherein the filter has at least one retentate side and at least one permeate side which are separated from one another by at least one filter medium, wherein the method comprises generating a pressure in a fluid, in particular in a liquid, on the retentate side or on the permeate side by means of a pressure source, in particular by means of a pump; switching off the pressure source; and the measurement of the pressure development in the fluid over time subsequent to the switching off of the pressure source.

The present invention relates to a method of identifying a filter, wherein the filter has at least one retentate side and at least one permeate side which are separated from one another by at least one filter medium, wherein the method comprises generating a pressure in a fluid, in particular in a liquid, on the retentate side or on the permeate side by means of a pressure source, in particular by means of a pump; switching off the pressure source; and the measurement of the pressure development in the fluid over time subsequent to the switching off of the pressure source.

The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.

The invention relates to a blood line (108) comprising an infusion site (145) intended to inject into the line a solution comprising: a first main channel (200) having a first passage section, a second main channel (220) having a second passage section, means for the formation (210) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means (224) defining a reduction (225) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, a secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.

A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.

A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.

Circulating cell clusters found in subjects with cancer, autoimmune conditions, infections, or other diseases, can be trapped or disrupted by filtering them with an intra- or extracorporeal device and, in some cases, exposing them to a substance, such as enzyme, that reduces intercellular adhesion.

A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a blood treatment or filtering device interposed between the bone and return ports thereby establishing a mini-circulatory system.

A device isolates a substance from blood. The substance includes particles with an effective diameter that is within a range defined by effective diameters of constituents of blood. The device comprises a first sheet of graphene including a first plurality of apertures. The first plurality of apertures are configured to pass objects with an effective diameter less than or equal to the effective diameter of the particles of the substance. The device comprises a second sheet of graphene including a second plurality of apertures. The second plurality of apertures are configured to pass objects with an effective diameter less than the effective diameter of the particles of the substance. The device may be configured to include a conduit system. The device may be configured to operate according to a reversible cycle.