A non-invasive ventilation system may include a nasal interface. The nasal interface may include a left outer tube with a left distal end adapted to impinge a left nostril, at least one left opening in the left distal end in pneumatic communication with the left nostril, and a left proximal end of the left outer tube in fluid communication with ambient air. The left proximal end of the left outer tube may curve laterally away from a midline of a face. A right outer tube may be similarly provided. One or more left jet nozzles may direct ventilation gas into the left outer tube, and one or more right jet nozzles may direct ventilation gas into the right outer tube. The jet nozzles may be in fluid communication with the pressurized gas supply.

A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.

The present disclosure relates to a transportable device for providing a cooled, oxygen-containing gas flow for supplying to a body of mammal via the respiratory tract, in particular a human being, in order to lower the body temperature. The device comprises a storage device comprising at least one fluid reservoir and at least one heat exchanger, wherein the storage device is designed to store an oxygen-containing fluid in the fluid reservoir and for providing a discharge flow of the oxygen-containing fluid. The heat exchanger is designed to cool the provided discharge flow by transferring heat to a cooling stream of a stored fluid and provided by the storage device, and a cooled, oxygen-containing gas flow for supplying to the body emerges from the heat exchanger.

The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

The current invention concerns a kit suitable for the non-surgical treatment of skin lesions including warts, verrucae, corns, and skin tags said kit comprising a cryogenic body comprising a housing hosting a coolant container and further comprising a cryogenic applicator head, whereby the housing and the cryogenic applicator head extend axially; said cryogenic applicator head is provided with a cryogenic tip for performing a cryogenic treatment to a skin lesion, whereby said coolant container contains a coolant suitable for cooling said tip; the kit further comprises an acid body comprising an acid container containing an acidic composition and having an acid outlet, and an acid dispenser head that axially extends from said acid container, is in fluid communication with said acid outlet, and is suitable for applying a dose of said acidic composition to a skin lesion. The invention also concerns a dosage regimen.

An apparatus for metering the delivery of an aerosol. The apparatus has a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus may also include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.

Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.

Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.

A container replacement system for replacing a fluid container with a replacement fluid container, wherein the fluid container contains a cryogenic fluid and is coupled to a pressure line, includes a control valve that vents the cryogenic fluid within the pressure line, a pressure sensor that senses a line pressure of the cryogenic fluid and generates sensor output and a controller that receives sensor output and determines whether to replace the fluid container. If the line pressure is below a threshold line pressure, the controller determines replacing the fluid container is permissible. Contrarily, if the line pressure is above the threshold line pressure, the controller determines replacing the fluid container is not permissible. The container replacement system further includes a GUI that instructs whether replacing the fluid container is permissible.