The invention provides liquid formulation compositions and medicament delivery devices, and methods for preparing and using the same. For example, the liquid formulation composition is an emulsion including a solvent and liquid particles, which includes surfactants and are dispersed in the solvent. The volume average particle size of the liquid particles is less than about 100 μm; the surface tension of the liquid formulation composition is less than about 60 mN/m; and the absolute value of zeta potential is greater than about 15 mV. The containment vessel may be a sprayer or a dropping device. The invention also provides methods for preparation of the liquid formulation compositions and medicament delivery devices as well as methods for using the same in treatment of various diseases and condition, for example, otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia (dry mouth), xerophthalmia (dry eyes) and xeromycteria (dry nose).

An interstitial fluid accumulation chamber is configured to be implanted in a mammal for use as a protective environment for transplanted cells. The interstitial fluid accumulation chamber includes opposed first and second members, a cell isolation chamber, and a plurality of spaced-apart members. The opposed first and second members are disposed in spaced-apart relation. The cell isolation chamber is disposed within and in-between the opposed first and second members. The cell isolation chamber includes a filter which contains pores sized to allow interstitial fluid to enter the cell isolation chamber while preventing cells within the cell isolation chamber from leaving the cell isolation chamber. The plurality of spaced-apart members are disposed within and between the opposed first and second members. The plurality of spaced-apart members form a tortuous path which is configured to prevent tissue from growing within the interstitial fluid accumulation chamber.

A medical placeholder. The medical placeholder has at least one hollow body which is expandable and which defines an interior space, a gas infeed hose which is connected or connectable in a gas-permeable manner with the interior space of the hollow body, and a gas discharge hose which is connected or connectable in a gas-permeable manner with the interior space of the hollow body. The hollow body consists partly or completely of at least one plastic material which is permeable to oxygen and carbon dioxide. A one-way valve is arranged in the gas infeed hose and a pressure relief valve is arranged in the gas discharge hose. Also disclosed is a method for gas-flushing a surface of a medical placeholder.

A medical fluid suspension generating delivery apparatus includes a dual syringe assembly including a first receptacle for a pressurized chemical solution and a second receptacle for a medical solution. The medical fluid suspension generating delivery apparatus also includes a Venturi-agitating tip assembly generating an enriched medical suspension from the pressurized chemical solution and a second receptacle for a medical solution.

The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

A waste liquid receptacle includes first and second cover members for covering first and second openings, respectively. The first cover member is made of a material that is configured to: (i) be plastically deformed upward by a first suction force in a state where a second negative pressure is generated in an upper space; and (ii) plastically deform downward by a depressing force against the first cover member downward in a state where an openable and closable lid is open and the second negative pressure is released. The second cover member is made of a material that is configured: (i) not to be plastically deformed by a second suction force in a state where a first negative pressure is generated in a waste liquid receipt space; and (ii) to be broken without being plastically deformed when a depressing force is applied to the first cover member.

A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.

A syringe-based device includes a housing and an actuator mechanism including a first member and a second member. The first member includes a syringe body and a plunger, the plunger being movably disposed within the syringe body. The second member includes a second member plunger seal and a valve operably and selectively coupled to the second member plunger seal such that the valve is positioned proximal of the second member plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which the first type of fluid is expelled from the first fluid reservoir, to a third configuration in which the second type of fluid is expelled from the second fluid reservoir through the valve.

A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.

A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.