An infusion pump system is operable to deliver blood to a patient from a first fluid reservoir via a first pump while mixing in a calcium-containing solution from a second fluid reservoir via a second pump. The controller precisely controls the amount of calcium-containing solution that is administered to the patient to be mixed with the blood infusate in the patient's bloodstream according to a preset blood-calcium ratio, thereby preventing citrate intoxication during large blood transfusions.

A nasal mucus suction device includes an air pump and a head structure. The air pump has an intake tube and an outlet tube. The head structure is coupled to the intake tube and the outlet tube of the air pump, and defines a channel between a nasal mucus suction inlet and a gas outlet. The channel includes a first channel section in communication with the nasal mucus suction inlet, and a second channel section in communication with the gas outlet. The first channel section includes at least one mucus storage cavity, the second channel section is in communication with the intake tube and the outlet tube of the air pump. The first channel section has a maximized path length, and includes an anti-backflow channel structure. The second channel section includes a noise reduction space.

The present disclosure provides devices for preventing or absorbing fluid (e.g., sweat) and/or odors from the intergluteal cleft of a subject. In some embodiments, the present disclosure provides devices for treating or preventing hemorrhoids and methods of using same.

A syringe-based device includes a housing and an actuator mechanism including a first member and a second member. The first member includes a syringe body and a plunger, the plunger being movably disposed within the syringe body. The second member includes a second member plunger seal and a valve operably and selectively coupled to the second member plunger seal such that the valve is positioned proximal of the second member plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which the first type of fluid is expelled from the first fluid reservoir, to a third configuration in which the second type of fluid is expelled from the second fluid reservoir through the valve.

A unit dose container for holding a single dose of a given liquid, the container comprising: a chamber (8) in which, in use, the given liquid is stored, the chamber having a wall through which, in use, the liquid is to be supplied; a release mechanism (7), at least part of which is internal to, or forms part of the wall of the chamber, the release mechanism being movable relative to the chamber between first and second positions; and means for allowing the release mechanism (7) to move from the first to the second positions, thereby opening a passage through the wall so that the liquid can exit the chamber (8), the means including at least one flexible wall portion.

The present disclosure provides devices for preventing or absorbing fluid (e.g., sweat) and/or odors from the intergluteal cleft of a subject. In some embodiments, the present disclosure provides devices for treating or preventing hemorrhoids and methods of using same.

Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g., to provide for controlled cessation of use or to provide a desired therapeutic window.

An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.

Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Provided are a reservoir assembly and a medical liquid injection device. The reservoir assembly includes a reservoir including a storage space for medical liquid, a plunger inserted into the reservoir and moving along the reservoir, a connector connected to the plunger and including at least a portion extending to an opposite side of the storage space, a guide member into which the connector is inserted and which guides movement of the connector, and a sensor unit installed on the guide member and sensing movement of the connector.