A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.

Some embodiments provided herein relate to methods, systems and kits for providing consistent intracoronary administration of a biologic to subjects having diverse coronary anatomies. In some embodiments, the biologic is an adeno-associated virus serotype 1 (AAV1) vector encoding sarcoplasmic/endoplasmic reticulum ATPase 2a (SERCA2a) protein.

A scalp treatment applicator assembly includes a tube which contains a fluid scalp treatment. A cone is fluidly coupled to the tube and the cone is in fluid communication with an interior of the tube to receive the fluid scalp treatment. The cone tapers to point to penetrate the user's hair to apply the fluid scalp treatment to the user's scalp without disturbing the user's hair. A bulb is removably attachable to the tube and the bulb is comprised of a resiliently deformable material such that the bulb can be compressed by the user. The bulb is in fluid communication with an interior of the tube when the bulb is attached to the tube to urge the fluid scalp treatment outwardly through the cone when the bulb is compressed.

A surgical system comprising a catheter comprising an irrigation tube, a suction tube, an occlusion balloon disposed about the irrigation tube and suction tube, and a console in operative communication with the irrigation tube and the suction tube. The surgical system also comprising a remote operations unit in communication with the console via a connector, wherein an input to the remote operations unit is communicated to the console, which in turn acts to operate the irrigation tube and suction tube in a manner corresponding to the input.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

There is provided an aerosolizable gel comprising (a) an active agent; (b) one or more gel forming materials, wherein the one or more gel forming material is at least one phyllosilicate; (c) an aerosol forming material selected from glycerol, propylene glycol and mixtures thereof; and (d) water.

A device is provided for delivering a predetermined volume of at least one substance within a body cavity of a subject. The device contains a) a capsule for containing the predetermined volume of substances; b) a delivery end, having at least one orifice of diameter D, for placement in proximity to the body cavity; c) a valve mechanically connectable to the capsule, having at least two configurations: (i) an active configuration in which the valve enables delivery of the substances; and (ii) an inactive configuration, in which the valve prevents delivery of the substances from the capsule to the body cavity; and d) a fluid tight chamber configured to contain predetermined volume V.sub.gas of pressurized gas at a predetermined pressure, P.sub.gas. The capsule further contains at least one mixing mechanism that mixes the substances and the pressurized gas after the valve is reconfigured to the active configuration.

The invention relates to an inhaler, particularly an electronic cigarette product, comprising at least one evaporator device having at least one electrical evaporator for evaporating liquid supplied to the evaporator and an electronic control device for controlling and/or regulating the evaporator. A plurality of liquids are associated or can be associated with the evaporator device in such a way that the composition and/or the vapour production rate of the vapour/aerosol produced by the at least one evaporator can be adjusted and/or modified in a targeted manner, as the control device is designed for individual control of the at least one or each individual evaporator and/or for group control of the evaporators.

An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

A negative pressure is generated in an upper space of a canister due to a suction force of a suction source and, then, a negative pressure is generated in a waste liquid receiving space of a cylindrical body in response to the generation of the negative pressure in the upper space . At this stage of the operation, a first covering member that covers a first opening that opens facing the upper space in a waste liquid treating agent storing portion plastically deforms upward by a suction force caused by a negative pressure in the upper space. On the other hand, when a depressing force that pushes the first covering member downward is applied to the first covering member in a state where an opening and closing lid of the canister is opened so that a negative pressure in the upper space is released, the depressing force is transmitted to a second covering member so that the second covering member is broken.