A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.

A nebuliser device with a vibrating mesh, for administering medicaments, includes a casing, a nozzle, a nebuliser and a chamber that houses a medicament. The chamber housing a medicament is a disposable capsule forming an independent body that can be extracted from the casing of the device. The disposable capsule includes a connector for attaching to the nebuliser and to the casing. The connector allow the disposable capsule to be coupled to the nebuliser device or uncoupled therefrom.

The invention relates to a fluid reservoir (2) for an aerosol generator (50), the fluid reservoir (2) comprising a fluid chamber (4) for receiving a fluid (6), an opening (8) for guiding the fluid (6) received in the fluid chamber (4) outside the fluid chamber (4), and a collar portion (10) surrounding the opening (8) and extending into the fluid chamber (4). A first portion (12) of the fluid chamber (4) extends along the length of the collar portion (10) in a height direction (H) of the fluid chamber (4), A second portion (14) of the fluid chamber (4) is arranged adjacent to the first portion (12) in the height direction (H) of the fluid chamber (4). A lateral extension of the first portion (12) in the directions perpendicular to the height direction (H) of the fluid chamber (4) is smaller than a lateral extension of the second portion (14) in the directions perpendicular to the height direction (H) of the fluid chamber (4). Further, the invention relates to a fluid reservoir (2′) for an aerosol generator (50), the fluid reservoir (2′) comprising a fluid chamber (4′) for receiving a fluid (6′), an opening (8′) for guiding the fluid (6′) received in the fluid chamber (4′) outside the fluid chamber (4′), a recess (9) arranged at least partly below the opening (8!) in a height direction (H) of the fluid chamber (4′), and a cover member (30′) which releasably or permanently seals the recess (9). Moreover, the invention relates to an aerosol generator (50) comprising the fluid reservoir (2, 2′).

Add-on module (100) for logging the value of an expelled dose from a pen-type drug injector (200), comprising a magnetic sensor system comprising first and second sensor means (745/746) as well as a mechanical dose setting and expelling mechanism comprising a magnetic clutch element (240/740) which rotates during drug expelling. The system further comprises processor means configured to determine (i) on the basis of measured values from the first sensor means, a rotational position of the clutch element, (ii) on the basis of measured values from the second sensor means, a high-speed condition in which the rotational speed of the clutch element exceeds a given threshold level, and (iii) indicate an error state if the high-speed condition is detected.

Face soaking devices (devices) and methods of use are described and disclosed. In some embodiments the device may comprise a vessel and a vessel neck gasket. The vessel may be configured to hold a liquid to submerge a face of a user or a portion thereof. The vessel neck gasket may be (removably) joined to the vessel. The vessel neck gasket may be configured to comfortably accommodate a portion of the user's neck. In some embodiments, the device may comprise a breathing apparatus that may be in removable contact with: the vessel, with a head rest subassembly, and/or with the user. The breathing apparatus may be configured to permit the user to breathe while the user's face may be submerged within the liquid. When the vessel may be filled with the liquid to at least a sufficient level, the user may soak the face or the portion thereof, such that the skin being soaked receives a benefit.

The invention related to a device (1) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir (10) for storing the liquid (L), a first electrode (100) being arranged at an outlet (11) of said reservoir (10), a second electrode (200) forming a counter electrode to the first electrode (100) for accelerating said droplets (D) along the spraying direction (S), and a housing (30) holding the reservoir (10) as well as said electrodes (100, 200).

A vaporization device and its method of use, where the device can accommodate a plurality of formulations for dispensing by selecting the desired source. Such formulations can include different drug formulations for providing different effects on the user. Also, an indicator with specialized indicia can be provided to identify the source being dispensed.

Provided is a method for cancer treatment in a patient comprising extracorporeal dialysis of blood, plasma or peritoneal fluid of the patient with a dialysis system for removing a target amino acid, and the dialysis system comprising: a dialysis machine, a dialyzer having a dialysis membrane, and a dialysate; wherein the dialyzer is connected to the dialysis machine and the dialysate flows within the dialysis machine and the dialyzer; and an enzyme for degrading the target amino acid is provided to the dialysis membrane and/or the dialysate, and the target amino acid includes asparagine, glutamine, arginine, serine, methionine or any combination thereof. By modifying dialysis to achieve in vitro amino acid deprivation and incorporating personalized diagnosis, the present invention not only provides a novel precision medicine with better anticancer efficacy and less side effects, but also requires less time and cost for development.

A dispenser device, including an outlet, air expeller including a piston that slides in an air chamber between rest position and dispensing positions, and a reservoir containing a dose composition. The reservoir includes an air inlet connected to the air expeller, and a composition outlet connected to the outlet, the air inlet including a composition retainer member, and the composition outlet being closed by a closure element force fitted in the composition outlet of the reservoir. A mechanical opening system co-operates with the closure element to expel it from its closed position while the device is actuated. The piston, when in its rest position, co-operates in non-airtight manner with the air chamber so that the air chamber communicates with the atmosphere. The piston includes an inner lip co-operating with a cylindrical surface, the cylindrical surface including fluting co-operating in non-airtight manner with the inner lip in the rest position.

Methods and devices are provided for delivering one or more substances within at least one body cavity. Such devices include at least one nosepiece having at least one capsule including a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base having at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF, and at least one hollow puncturing member having at least one sharp end and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by at least one hollow tube. A fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with at least one end of the at least one puncturing member.