A treatment system delivers a breathing gas and frozen ice or other particles (FSP) to a bronchus of a lung of a patient in order to induce hypothermia. The breathing gas and the FSP are usually delivered through separate lumens. Clogging of an FSP lumen can be inhibited by heating and/or cooling of the lumen. The temperature of exhaled gases or a body temperature may be measured, and a controller can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured temperature.

Methods, systems, and devices are disclosed for facilitating delivery of microvesicles or stem cells across the blood brain barrier (BBB). A pressure device is used to target a region of a patient's brain. The pressure device delivers a shockwave to the targeted region, facilitating delivery of a microvesicle or stem cell at the targeted region. The shockwave does not damage brain tissue and does not disrupt or tear the BBB. A microvesicle or stem cell, or both, is administered to the patient and crosses the BBB at the targeted region, without damaging, tearing, or disrupting the BBB.

An aerosol generating device which can infer or detect the state of at least one of a storage and a receptacle for an aerosol source, the aerosol generation device includes: a load which atomizes the aerosol source by generating heat with power supplied from a power source; a sensor which outputs values relating to the temperature of the load; and a controller. The controller infers or detects the state of at least one of the storage and the receptacle based on at least an output value of the sensor in a first power supply cycle, an output value of the sensor in a second power supply cycle, or a value relating to behavior of the temperature of the load in the second power supply cycle.

A laser heater assembly for a vaporizer includes a power source, a laser source, a lens, and a reaction chamber. The lens is disposed within the optical path. During operation, the laser source emits light, the light propagating along an optical path during operation of the light source. The lens receives the emitted light from the laser source, and outputs a modified light having an energy profile that is substantially spatially uniform. The modified light traverses at least a portion of an opening of the reaction chamber and vaporizes a vaporization substance (e.g., a dry plant material) received within the reaction chamber. The emitted light can be collimated light, and the modified light can be a homogeneous line profile beam.

An aerosol-generating system includes a rotating heating clement having two or more heating surfaces in the aerosol-generating device. The aerosol-generating device receives a replaceable aerosol-generating article. The replaceable aerosol-generating article includes a tape having a solid aerosol-generating substrate on the tape. Methods of using the aerosol-generating system are also described.

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

In a transfer instrument, a medical sheet is supported by a first support surface of a first support portion and a second support surface of a second support portion. The second support portion has a shape tapered in a distal end direction of the transfer instrument.

Wound management assemblies, kits, and methods are disclosed. A wound management assembly can include a guidewire and a wound matrix compressed onto the guidewire. The wound matrix can optionally be derived from a perfusion-decellularized mammalian tissue or organ. The assembly can further include a tamp member positioned on the guidewire, proximal to a position of the wound matrix. The assembly can be delivered to a desired location within a wound bed using the guidewire or using an introducer set included in a kit. A method can include navigating the wound management assembly to the entrance of the wound bed, using the tamp member to distally urge the wound matrix into the wound bed, and subsequently removing the tamp member, the guidewire, and a sheath if used.

A transfer instrument is provided with a carrier holding portion at a distal end of a second shaft. The carrier holding portion includes a pressing surface and a first projection. The pressing surface presses a medical sheet supported on a first support surface of a first support portion in a distal end direction. The first projection is provided remote from the first support surface relative to the pressing surface and protrudes in the distal end direction relative to the pressing surface.