Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols including particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter.

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

The invention relates to a predonation bag system comprising a predonation bag to be filled with whole blood during the blood removal. an anticoagulant being added to the whole blood in the predonation bag and sample containers being automatedly filled with the whole blood from the predonation bag only in the laboratory for blood analysis. The predonation bag system is part of a blood bag system. The invention also relates to corresponding method for removing blood by means of the predonation bag system and for analyzing the whole blood of each donor.

A vacuum aspiration system and methods of use are disclosed. The system and method can be configured to provide deep pulsatile suction to a catheter body to more efficiently aspirate a clot material from a patient. In some embodiments, a deep pulse can include a rapid increase in flow rate of the fluid through the catheter body to a sustained high flow rate range for a short period of time followed by a rapid decrease in the flow rate to a low or negligible flow rate level to minimize blood loss without any changes to the suction pressure being applied to the catheter.

A MAP and applicator system can include a MAP and an applicator. The MAP can include a backing and a plurality of microneedles extending from the backing. The microneedles can include tips with a GLP-1 agonist; and a water-soluble base configured to at least partially dissolve upon contact with a bodily fluid of a subject causing the tip to be released below the skin. The applicator is configured to maintain the MAP; in response to an activation mechanism being activated, release a piston downward into the MAP; and push, via the piston, the MAP downward onto the skin surface of the subject such that the plurality of microneedles penetrate the skin surface and are delivered. Apexes of the microneedles are delivered to the subject at a depth of at least about 600 m and at least about 70% of the GLP-1 is delivered after release of tips of the microneedles.

The present disclosure provides methods and systems for removing particles from an individual using plasmapheresis, including from an individual's circulatory system, blood vessels, and/or organs. In various embodiments, the particles removed are plastic particles. In further embodiments, the present disclosure provides methods for treatment by reducing levels of particles in an individual's circulatory system, blood vessels, and/or organs.

A method of treating diverticulitis and the diverticulum by reducing the bioactivity of the diverticulum such that the diverticulum necroses. The devices and methods include placing an endoscopic device within a colonic lumen relative to at least one diverticulum and inverting the diverticulum. Once inverted, the diverticulum is collapsed and sealed. Overtime, the inverted diverticulum will necrose and be absorbed by the body or slough off and be expelled.

An oral device or mouthguard device containing a reservoir for holding and passively releasing an active component is provided. An oral device or mouthguard device having a body with an inner wall, an outer wall, a floor spanning the inner wall and outer wall. The inner wall, the outer wall, and the floor define a channel including an interior channel surface and an exterior channel surface. The interior channel surface shaped to receive a plurality of teeth. A reservoir integral with the inner wall is also included. The reservoir has a roof portion and a base portion defining an internal volume for an active component. The roof portion has an opening for receiving the active component and the base portion has one or more openings.

An aspiration catheter may include a tubular body having a proximal end, a distal end, and a lumen extending therethrough. The distal end of the tubular body can be configured to provide aspiration in a first aspiration mode to apply a tension force to a clot positioned near the distal end along a longitudinal axis of the tubular body. The aspiration catheter can be configured to provide aspiration in a second aspiration mode at least when the clot is positioned within the distal end of the tubular body to apply a second force to the clot along a second axis different from the longitudinal axis. The catheter can include a stent-like backbone positioned along a sidewall of the catheter. The stent-like backbone can include a metallic support having a continuous gap extending longitudinally along a length of the backbone.

A method of aspirating a hematoma from a body space via a catheter coupled to a pump assembly includes advancing a tip of the catheter into proximity with the hematoma within the body space. The pump assembly includes a pump, a motor, a sensor, and a controller. The method further includes actuating the pump assembly to: operate the pump in a first mode during which the motor drives the pump at a first aspiration speed; receive at the controller a pressure signal associated with a catheter pressure from the sensor of the pump assembly; and on a condition that the catheter pressure is below a pressure threshold, operate the pump in a second mode during which the motor drives the pump cyclically between a second aspiration speed and an infusion speed such that the catheter pressure cycles between an upper pressure limit and a lower pressure limit.