A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.

The present invention provide a puncture instrument capable of administering (supplying) a drug solution. The puncture instrument includes a puncture tip section (2); a first tubular body (3) connected to the puncture tip section (2) at the distal end; and an outer tubular body (5) at least partially covering the first tubular body (3). The first tubular body (3) is formed to be rotatable around an axis along the longitudinal direction. The first tubular body (3) has an outer diameter smaller than an inner diameter of the outer tubular body (5). A drug solution supply path (5a) is provided on the outside of the first tubular body (3).

A bone harvesting device includes a main body having an internal cavity and a suction port adapted to be coupled to a suction source. The device further includes an outer tube (200) having an interior surface, an exterior surface, a proximal end and a distal end, the proximal end of the outer tube being coupleable to the main body, an inner tube having an interior surface, an exterior surface, a proximal end and a distal end, the inner tube being in fluid communication with the internal cavity and at least partially disposed within the outer tube such that a venting channel is defined between at least a portion of the inner tube and at least a portion of the outer tube.

An intraosseous device, comprising a cannula through which life-saving fluids are transfusible into or out of bone marrow of a target bone when the cannula is penetrated into the target bone; a stylet which is engageable with the cannula; and means for causing penetration of the stylet and cannula, when mutually engaged, to a predefined depth within the target bone with respect to an outer surface of the target bone, the depth being irrespective of a thickness of tissue above the target bone.

A device comprising a trocar having a first end and comprising a cannulation and at least one fenestration proximal the first end; and a housing comprising a first port configured for the attachment of a first syringe and a second port configured for the attachment of a collection vessel, a first valve configured to selectively permit fluid flow through the cannulation of the trocar to the first port, and a second valve configured to selectively permit fluid flow through the cannulation of the trocar to the second port. The device allows the first syringe to draw up bone marrow in small volumes with high vacuum and then transfer the small draws into the collection vessel. The device may increase the recovery of desired cells residing in the bone marrow to be recovered during a bone marrow aspiration procedure.

The present invention discloses bone needle clamps and cannulated needle pins for use as skeletal infusion needles and methods therein. Bone needle clamps for facilitating intraosseous (IO) fluid transfer include: a clamp assembly having: at least one pair of opposing tips, facing each other, with each of the tips having a sharp end; and a bore in each tip, wherein the bore has a connection-facing opening and a bone-facing opening at opposing ends of the bore, and wherein the bone-facing opening is disposed in the tip at least one millimeter from the sharp end of each tip; and a needle assembly having: a cannula integrally attached to the connection-facing opening of the bore of the clamp assembly; and a connector operable to releasably attach a fluid-transfer assembly; wherein the needle assembly is operable to facilitate 10 infusion to the subject's bone and/or bone-marrow (BM) aspiration from the subject's bone.

An embodiment includes a system comprising: a lower piston in a lower chamber and an upper piston in an upper chamber; a filter between the lower and upper pistons; at least one processor and memory to: move the lower piston away from the filter, while the upper piston is still, to draw bone marrow aspirate (BMA) into the lower chamber from an external container; move the lower piston towards the filter while simultaneously moving the upper piston away from the filter to advance BMA fluid of the BMA from the lower chamber across the filter and into the upper chamber and to locate BMA cells of the BMA adjacent the filter and within the lower chamber; move the lower piston toward the filter, while the upper piston is still, to advance the BMA cells out of the lower chamber and into one of the external container and another external container.

A blood component separator (1) includes a blood storage vessel (20) that includes a first storage part (21) and a second storage part (22), a slider (30) movable from the first storage part to the second storage part, and a flow path (40f) for communicating an inside and an outside of the storage vessel. When the slider is in the first storage part, the first storage part and the second storage part are in communication with each other. When the slider is inserted into the second storage part, a liquid-tight seal is formed between the slider and the inner peripheral surface of the second storage part and the communication between the first storage part and the second storage part is blocked by the slider. The slider is movable in the second storage part while maintaining the liquid-tight seal between the slider and the inner peripheral surface of the second storage part. As the slider enters the second storage part, the blood component in the second storage part is pushed out of the storage vessel through the flow path.

A method for delivering multiple substances in a delay fashion to a bone of a patient is provided. The method includes providing a cannulated bone screw, creating an aperture in the skin of a patient, and inserting the bone screw into a bone of the patient through the aperture. The method further includes delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into a solid hardened material, and then delivering a second substance into the bone through the bone screw after the first substance changed into a solid hardened material. The solid hardened material of the first substance may be a permeable material that allows the second substance to transport through, or the second substance may transport through the first substance by diffusion, or may reach a desired location in the bone through pores or cracks in the hardened solid material.

A device and method for aspirating bone barrow. The device includes a double syringe assembly having a distal syringe and a proximal syringe coupled to the distal syringe. A plunger includes a distal end disposed within a barrel of the distal syringe and a proximal end disposed within a barrel of the proximal syringe. A needle assembly is coupled to the double syringe assembly and includes a needle having an outer tube and an inner tube disposed within the outer tube. Upon actuation of the plunger, the distal syringe aspirates bone marrow through the outer tube of the needle and into a chamber of the distal syringe. At the same time, the proximal syringe injects fluid through the inner tube of the needle at the same rate in which the bone marrow is aspirated.