The diaphragm for alkaline water electrolysis according to the present invention comprises a porous polymer membrane, the porous polymer membrane comprising a polymer resin and hydrophilic inorganic particles. A porosity of the porous polymer membrane is 30% or more and 60% or less, average pore sizes at both surfaces of the porous polymer membrane is 0.5 μm or more and 2.0 μm or less, and a ratio of a mode particle size of the hydrophilic inorganic particles to the average pore size of the porous polymer membrane (mode particle size/average pore size) is 2.0 or more.

To provide a decorative film in which swelling of a layer containing a fluorinated polymer is suppressed and adhesion of the layer containing the fluorinated polymer is excellent; and a method for producing a three-dimensional molded product provided with a decorative film. The decorative film is characterized by comprising a base film containing a plasticizer; a first layer containing at least one member selected from the group consisting of a polyvinylidene fluoride, a polymethyl methacrylate and a polyurethane; and a second layer containing a fluorinated polymer comprising units based on a fluoroolefin and units based on at least one type of non-fluorinated monomer selected from the group consisting of a vinyl ether, a vinyl ester, an allyl ether and an allyl ester, in this order; wherein the water contact angle of the surface on the first layer side of the second layer is larger than the water contact angle on the second layer side of the first layer, and the difference between the water contact angle of the surface on the first layer side of the second layer and the water contact angle of the surface on the second layer side of the first layer is more than 0° and at most 50°.

A composition comprising an insulin-polymer conjugate and an insulin aptamer-glucagon conjugate is described. Depending upon the amount of insulin in the environment surrounding the composition, the insulin aptamer of the insulin aptamer-glucagon conjugate can bind to insulin in the insulin-polymer conjugate to form a non-covalent conjugate. When the amount of insulin in the surrounding environment rises, the insulin aptamer-glucagon conjugate can be released. Thus, the composition can be used to deliver glucagon in an insulin responsive manner. The composition can be loaded into microneedles, for example, to prepare microneedle arrays for skin patches. Methods of delivering glucagon to a subject are also described.

Methods of fabricating a hydrogel tube, and related systems, employ extrusion of a cross-linkable hydrogel solution from an annular outer nozzle of a nozzle assembly to form a cross-linkable hydrogel tube. The cross-linkable hydrogel tube is cured to form a cross-linked hydrogel tube. A second hydrogel solution can be coextruded via the axial inner nozzle to form an inner hydrogel filament coaxially positioned within the cross-linkable hydrogel tube. The cross-linked hydrogel tube can be functionalized with collagen to enable cell adhesion, and cells can be cultured on the luminal surfaces of these tubes to yield tubular endothelial layers. A 3D printed coaxial nozzle can be used to fabricate biofunctional tubular conduits that can be utilized for engineering in vitro models of tubular biological structures.

Drug delivery devices having a drug-permeable component and methods of making and using the same are provided. Drug delivery devices include a housing having a first and second wall structures that are adjacent one another and together form a tube defining a drug reservoir lumen. The second wall structure, or both the first wall structure and the second wall structure, are permeable to water, and the first wall structure is impermeable to the drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.

Embodiments of the present disclosure relate to advanced polishing pads with tunable chemical, material and structural properties, and new methods of manufacturing the same. According to one or more embodiments of the disclosure, it has been discovered that a polishing pad with improved properties may be produced by an additive manufacturing process, such as a three-dimensional (3D) printing process. Embodiments of the present disclosure thus may provide an advanced polishing pad that has discrete features and geometries, formed from at least two different materials that include functional polymers, functional oligomers, reactive diluents, addition polymer precursor compounds, catalysts, and curing agents. For example, the advanced polishing pad may be formed from a plurality of polymeric layers, by the automated sequential deposition of at least one polymer precursor composition followed by at least one curing step, wherein each layer may represent at least one polymer composition, and/or regions of different compositions. Embodiments of the disclosure further provide a polishing pad with polymeric layers that may be interpenetrating polymer networks.

Techniques for overmolding a composition onto a substrate are disclosed. More particularly but not exclusively, techniques for overmolding a therapeutic composition onto a substrate configured for delivery of the composition to teeth and/or oral tissue are disclosed. The overmolding techniques may include injection molding the therapeutic composition onto the substrate, and the therapeutic composition may include one or more therapeutic agents effective for treating one or more oral conditions.

A composition comprising an insulin-polymer conjugate and an insulin aptamer-glucagon conjugate is described. Depending upon the amount of insulin in the environment surrounding the composition, the insulin aptamer of the insulin aptamer-glucagon conjugate can bind to insulin in the insulin-polymer conjugate to form a non-covalent conjugate. When the amount of insulin in the surrounding environment rises, the insulin aptamer-glucagon conjugate can be released. Thus, the composition can be used to deliver glucagon in an insulin responsive manner. The composition can be loaded into microneedles, for example, to prepare microneedle arrays for skin patches. Methods of delivering glucagon to a subject are also described.

Embodiments of the present disclosure relate to advanced polishing pads with tunable chemical, material and structural properties, and new methods of manufacturing the same. According to one or more embodiments of the disclosure, it has been discovered that a polishing pad with improved properties may be produced by an additive manufacturing process, such as a three-dimensional (3D) printing process. Embodiments of the present disclosure thus may provide an advanced polishing pad that has discrete features and geometries, formed from at least two different materials that include functional polymers, functional oligomers, reactive diluents, addition polymer precursor compounds, catalysts, and curing agents. For example, the advanced polishing pad may be formed from a plurality of polymeric layers, by the automated sequential deposition of at least one polymer precursor composition followed by at least one curing step, wherein each layer may represent at least one polymer composition, and/or regions of different compositions. Embodiments of the disclosure further provide a polishing pad with polymeric layers that may be interpenetrating polymer networks.

The invention relates to a method for creating a surface structure on a mold, wherein first structural elements are created using a laser structuring process in a first step, and second structural elements, which are smaller than the first structural elements, are created using an anodic oxidation process in another step following the laser structuring process. The invention further relates to a mold of said type and finally to a plastic film or a plastic component having a surface structure as well as to a method for the production thereof.