The present disclosure provides methods and systems for treating a biological fluid of a subject suffering from a microbial infection (e.g., a drug-resistant microbial infection). In some embodiments, these methods and systems involve a complement receptor immobilized on, or otherwise associated with a polymer substrate, for example, high surface area particles, membranes, hollow fibers, and/or other porous or non-porous media. In other embodiments, the methods and systems involve a complement receptor present in a dialysate used in a dialyzer for extracting pathogens out of a biological fluid, for example, the blood of a patient.

A system, device, and autologous method for treating blood. Blood is extracted from a patient. The blood is tested to determine one or more pathogens and conditions of the blood. One or more catalysts are automatically added into the blood of the patient. The one or more catalysts are activated utilizing the one or more emitters configured to interact with the one or more catalysts in the blood create treated blood. One or more additives are added into the threated blood. The treated blood is reinjected into the patient.

The present invention relates to a device for the treatment of blood comprising a solid phase on which a polypeptide is immobilized which is suitable for the inactivation of free nucleic acids. Suitable polypeptides are, for example, deoxyribonucleases, ribonucleases, DNA methyltransferases or cytosine deaminases. The invention further comprises the use of such devices for the treatment of patients suffering from chronic kidney failure, cancer or lupus erythematosus, as well as methods and systems for the treatment of blood, wherein free nucleic acids are inactivated outside the body.

A diagnostic tool can include a face mask, a casing, a plurality of sensors, and processing circuitry. The face mask can include an air-intake port, a first check valve integrated into the air-intake port, an air-exhaust port, and a second check valve integrated into the air-exhaust port. The casing can be coupled to the face mask having an air-intake chamber coupled to the air-intake port and an air-exhaust chamber coupled to the air-exhaust port. The processing circuitry can be communicatively coupled to the plurality of sensors. The processing circuitry can include computing logic for handling information detected by the plurality of sensors.

The disclosure relates to methods for therapeutically targeting circulating tumor cells during hemodialysis, comprising: connecting a patient's bloodstream to a flow electroporator device, the device comprising: an array of polymeric channels, where the opposing sidewalls of each channel are lined with discontinuous sections of electrodes, interspersed by non-conductive polymer sections to generate sequential electric fields by constant direct current voltages; sequential electric fields with independently regulated intensity, duration, and polarity to induce lysis of circulating tumor cells and deliver chemotherapeutic agents to reduce the viability of circulating tumor cells; and polymeric tubing inlet and outlet for seamless integration into the bloodline tubing of any hemodialysis machine

Techniques and devices for filtering dialysis fluids, such as dialysis effluent, are described. For example, a filter device may be configured to filter peritoneal dialysis (PD) effluent draining from a patient during a PD process. The filter devices may include filters configured to filter materials, such as human cells, microorganisms, and/or other components from PD effluent. For instance, a filter device may be configured to be installed in-line in a drain circuit of a PD system using conventional tubing. The captured materials may be analyzed or otherwise processed to determine health characteristics of a patient and/or to capture stem cells. Other embodiments are described.

The invention discloses a decontamination device for decontaminating inhaled and/or exhaled gases in a ventilator. The decontamination device comprises a gas inlet and outlet for inspiratory and expiratory gas flow, and a chamber for gas flow. The chamber is configured to connect the gas inlet and outlet. The chamber comprises at least one ultraviolet (UV) light source integrate inside the chamber that preferably emits in the UVC range, wherein the UV light source is preferably a UVC light-emitting diode. The UV light source is configured to produce UV light to decontaminate contaminants in the inhaled and/or exhaled gases by minimizing the distance between the contaminants in the gas flow and the light source, maintaining the gas flow in a gas flow path long enough to deactivate the contaminants, increasing the intensity of the light source to optimize decontamination, and increasing turbulence to redirect the gas flow and prevent boundary layers and shadowing.

A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device. An acyloxyacyl hydrolase enzyme may also be used on the biochemical reactor surface.

An extraction arm for an extraction device includes a suction pipe and a suction head and defines a suction path that extends from an extraction region in the surroundings of the suction head through the suction pipe to the extraction device. The extraction arm includes an exchangeable filter which is arranged within the suction path. The filter is located in a filter housing which has a main body and a closable cover. The filter is exchangeable, which makes it very easy to prepare the extraction arm for a new application. Since the filter is arranged in front of the suction pipe, the suction pipe remains clean. The filter can easily be changed, whereby disinfection or cleaning of the suction pipe is not necessary.

A collector (1) for collecting a liquid resulting from a nasal wash, the collector (1) comprising a funnel-shaped body (10) which terminates in a duct (12) that extends between an inlet (14) and an outlet portion (16) provided with coupling members (160) pre-arranged for coupling in a fluid-tight manner with a test tube (162) through a respective mouth (164); the duct (12) having filtering members (20) for the liquid.