A syringe having a front portion carrying a hollow, axially extending needle, a container, running from said front portion and forming a container rear end portion, a plunger, extending and being movable axially in the container, the needle rear end being in fluid connection with the container and the: plunger being arranged to suck liquid, through the needle when drawn away from the needle and to discharge liquid through the needle when pushed towards the needle, the plunger having a piston portion, turned to the needle rear end, and a coupling portion arranged to co-act with the piston portion for moving the piston portion in the container. The syringe is especially characterized in that the container wall is made of a material having a certain resiliency and an inner diameter smaller than the outer diameter of the piston portion, such that a sealing action appears between the container and the piston portion.

A method for targeting epidermal delivery of an agent of interest is provided, where the method includes inserting at least one microneedle into the skin of a patient at a non-perpendicular angle, the at least one microneedle having the agent of interest. The at least one microneedle may be inserted into the skin of a patient using a system including the at least one microneedle and an angled insertion apparatus.

A dermal patch system for administering a pharmaceutical includes a vial that stores a pharmaceutical and a cartridge coupled to the vial. The cartridge includes a pull mechanism, a pump, a plurality of microneedles in communication with the vial. The microneedles are configured to move between an undeployed position to a deployed position. When pulled, the pull mechanism is configured to cause the microneedles to move from the undeployed position to the deployed position and cause the pump to pump the pharmaceutical from the vial and to the microneedles.

The present invention is directed to a needle sensor assembly and a method of using same. The needle sensor assembly includes a needle sensor housed within the needle sensor assembly. The needle sensor assembly is configured to be attached to an injection device. When the needle sensor assembly is attached to the injection device, the needle sensor is configured to detect if a needle positioned for use in the injection device is misaligned, absent, or broken.

The present invention relates to a microneedle system (MNS for short) for the intradermal application of a hepatitis vaccine, namely the antigen HBsAg.

A microneedle assembly that is capable of transdermal delivery of a drug compound, such as a vaccine, (e.g., vaccine) across a dermal barrier of a subject (e.g., human), and/or detecting the presence of an analyte in the subject is provided. The microneedle assembly comprises a plurality of microneedles arranged on a support that each contain a tip and base, one or both of which are formed from a polymer composition that includes a liquid crystalline polymer. By selectively controlling the specific components of the polymer composition, as well as their relative concentration, the resulting microneedles may exhibit a high degree of physical alignment, which can help ensure better performance during use of the microneedle assembly.

An apparatus for delivering an active ingredient into the skin of an animal at a defined depth, the apparatus including: a microprojection array including a plurality of microprojections having a density of at least 2,000 projections per cm.sup.2; and an applicator that drives the microprojection array towards the skin in use so that the microprojection array impacts on the skin with a mass-to-velocity ratio of between 0.0005 g/m/s and 0.1 g/m/s per cm.sup.2.

Disclosed herein are respiratory syncytial virus vaccines and methods of immunization to deliver respiratory syncytial virus vaccines in subjects.

Disclosed herein are respiratory syncytial virus vaccines and methods of immunization to deliver respiratory syncytial virus vaccines in subjects.

A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.