Encapsulation devices, systems and methods are provided. In some embodiments, encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host are provided. Encapsulation devices are provided that include a matrix or scaffold within a cell-receiving area or void, and methods of forming and preparing such a matrix are disclosed. Encapsulation devices that include channels are further provided, and the channels of the present disclosure are operable to convey fluid to internal areas of devices without restricting vascularization.

A blood pump having a housing including an inlet element. The inlet element has a proximal portion sized to be received within at least a portion of a heart of a patient and defines a major longitudinal axis. A rotor is configured to rotate within the housing about the major longitudinal axis and impel blood from heart. At least one stator is disposed within the housing and positioned within the housing at least one from the group consisting of upstream and downstream from the rotor. During operation of the blood pump the rotor is maintained at an oblique angle with respect to the major longitudinal axis.

A tissue expander can be configured to collect extracellular fluid from within a patient’s body cavity. The tissue expander can be implanted into a subdermal cavity during a procedure, such as a breast reconstruction procedure, and facilitate the expansion of the subdermal cavity in preparation for placement of a final implant.

The present invention provides systems, methods, and articles for stress reduction and sleep promotion. A stress reduction and sleep promotion system includes at least one remote device, at least one body sensor, and at least one remote server. In other embodiments, the stress reduction and sleep promotion system includes machine learning.

An adaptive system for efficient and long-range wireless power delivery using magnetically coupled resonators responds to changes in a dynamic environment, and maintains high efficiency over a narrow or fixed frequency range. The system uses adaptive impedance matching to maintain high efficiency. The wireless power transfer system includes a drive inductor coupled to a high-Q transmitter coil, and a load inductor coupled to a high-Q receiver coil. The transmitter coil and receiver coil for a magnetically coupled resonator. A first matching network is (i) operably coupled to the drive inductor and configured to selectively adjust the impedance between the drive inductor and the transmitter coil, or (ii) is operably coupled to the load inductor and configured to selectively adjust the impedance between the load inductor and the receiver coil.

A fluid management system for the treatment of ascites, pleural effusion or pericardial effusion is provided including an implantable device including a positive displacement gear pump coupled to an inflow catheter and an outflow catheter, a battery, a processor, and at least one sensor configured to detect a presence of an infection marker, and an external charging and communication system configured to wirelessly communicate transcutaneously with the implantable device. The processor is programmed to periodically activate the pump to move fluid from a first cavity to a second cavity, e.g., the patient's bladder, via the inflow and outflow catheters; receive a signal indicative of the presence of the infection marker from the at least one sensor; generate an alert upon receipt of the signal; and communicate the alert to the external charging and communication system to notify the user.

Encapsulation devices are provided that comprise an outer wall defining an inner volume, the outer wall comprising a plurality of pores and a plurality of vasculature holes; and a plurality of channels traversing the inner volume, wherein each channel extends from one of the plurality of vasculature holes to another of the plurality of vasculature holes. The device is used for the implantation or delivery of cells, proteins, or other therapeutic molecules. Also provided are methods of treating a disorder in a subject using an encapsulation device described herein. The disclosed encapsulation devices have a porous surface and an internal network of channels passing through the device and connecting with the outside of the device.

An intravascular blood pump has an intake filter that reduces risk of heart tissue being sucked into an intake port of the pump. The filter defines a plurality of apertures, through which blood flows through the filter. The apertures are sized to prevent ingestion, by the input port, of the heart tissue. The filter includes a plurality of generally helical first struts wound about a longitudinal axis of the filter, and a plurality of second struts. The first and second struts collectively define the plurality of apertures therebetween. The struts may be woven filaments, or the apertures may be defined in a thin film (foil) tube, where remaining material between the apertures form the struts.

The illustrative embodiments described herein are directed to systems, methods, and apparatuses for applying a reduced pressure to a subcutaneous tissue site. In one instance, a manifold for applying reduced pressure to a subcutaneous tissue site includes a plurality of first conduits, each of the plurality of first conduits having a wall with at least one first aperture and at least one second aperture. At least one of the plurality of first conduits is operable to deliver reduced pressure to the subcutaneous tissue site. The plurality of first conduits is coupled in a spaced arrangement that forms an interior space. The manifold further includes a second conduit comprising the interior space and formed by a portion of each wall of the plurality of first conduits. The second conduit is in fluid communication with the plurality of first conduits via the at least one second aperture.

The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.