Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

A rechargeable therapeutic system for treating conditions of a user's nasal cavities, sinuses or ear canals includes a therapeutic device having a housing that includes an inlet that allows air to enter the therapeutic device. An acoustic vibrator located within the housing provides an acoustic vibration to the user, and a power supply located within the housing provides power to the acoustic vibrator. A mask is connected to the housing and configured to be applied around the nose of the user. A valve of the mask is configured to allow the user to breathe through the inlet. The mask further includes a diaphragm and a nasal cavity in which the user's nose is located when the mask is applied around the nose of the user. A recharging station is configured to provide a charging current to the power supply.

The wound treatment apparatus combines an internal negative pressure (vacuum) pump and an internal positive pressure (compressor) pump connectable to an external oxygen supply for providing both negative pressure wound therapy and hyperbaric oxygen wound therapy to a wound site. The apparatus also includes a user interface operatively connected to an electronic controller that monitors and actuates the vacuum and compressor pumps. The user interface and controller enables the apparatus to provide multiple modes of operation and the ability to selectively change between negative pressure therapy operational modes and hyperbaric oxygen operational modes.

The invention relates to a respiratory assistance apparatus for delivering a respiratory gas, such as air, to a patient during cardiopulmonary resuscitation (CPR), having a source (1) of respiratory gas, means (4) for measuring the CO.sub.2 content, and signal-processing and control means (5). The signal-processing and control means (5) are configured to process the CO.sub.2 content measurement signals corresponding to measurements performed by the CO.sub.2 content measurement means (4) during a given period of time (dt), and to calculate at least one mean CO.sub.2 content value (Vmean) from the maximum CO.sub.2 content values (Vmax) obtained over the time window (Ft), and to transmit said at least one mean CO.sub.2 content value (Vmean) to the graphical user interface (7) which displays it.

A positive pressure ventilation (PPV) elbow connects to a PPV mask and a source of pressurized air from a ventilator. The elbow and includes an access valve that opens to provide access to the mouth of the patient without removing the mask and self-seals under pressure from the ventilator.

Methods and devices related to the fields of skin care, hair restoration and lip care wherein the systems may be used by an individual for infusing treatment media into skin or lips for cosmetic and rejuvenation purposes, hair restoration purposes or other therapeutic purposes.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

A head up CPR system may include a base and an upper support coupled with the base and configured to elevate a patient's upper body. The system may include a chest compression device that is coupleable with one or both of the base and the upper support and a positive pressure ventilation system that is coupleable with the base.