An apparatus for administering a cancer drug, comprising an optical emitter operatively arranged to emit a visible point of light onto a tissue surface to be treated, a robotic arm, operatively arrange to move a drug-delivery device, in sequence, to each of a plurality of predetermined positions within the tissue to be treated, a tactile sensor operatively arranged at the distal end of the drug-delivery device to determine vertical height movement of the robotic arm for contact of the tissue surface to be treated, a reservoir arranged to store the cancer drug, a needle, operatively arranged to be moved to each of the specific positions within the tissue, and to deliver the drug at those positions, and, a torch head for generating non-thermal plasma in proximity to an end of the needle and the area to be treated.

The present invention provides a method for treating a dermatological condition in a subject, comprising administering to the subjects skin a bioactive composition using a microneedle delivery device, wherein the bioactive composition comprises an effective amount of an anesthetic; administering an effective amount of electromagnetic radiation to the subjects skin to induce damage to the epidermis and/or dermis; and optionally administering to the subjects skin an effective amount of a composition to promote wound healing.

A catheter directionally conducts a pulsating body fluid and has a line segment defining an inner volume. A pump chamber section is arranged proximally as an extension of the line segment and defines a pump chamber having a frame therein accommodating a balloon. A first opening connects the inner volume to an external volume and a second opening is arranged proximally from the first opening to connect the inner volume to the external volume. A check valve is assigned to the second opening and the check valve includes a valve foil having an aperture formed therein offset from the second opening. A third opening communicates with the pump chamber. The frame is of a shape memory material which provides rigidity for a pulsatile operation of the balloon. During operation, the pulsating body fluid is conveyed in the inner volume directionally between the first and second opening by operating the balloon.

A waste collection system for collecting medical/surgical waste. A mobile rover includes at least one waste container supported on the mobile rover for storing the medical/surgical waste. A chassis is separate from and configured be removably coupled with the mobile rover. The chassis supports a chassis controller and a vacuum pump configured to draw a vacuum on the waste container. A rover controller is supported on the mobile rover and configured to receive a pressure signal representative of a level of the vacuum. The chassis controller is configured to be in communication with the rover controller and to regulate the level of the vacuum drawn based on the pressure signal. A transmitter may be supported on the mobile rover and in communication with the rover controller, and a receiver may be supported on the chassis to be in communication with the transmitter to establish a communication circuit for data transfer.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta. The system may also include one or more sensors for measuring physiological information indicative of blood flow through the aorta, and a non-transitory computer readable media having instructions stored thereon, wherein the instructions, when executed by a processor coupled to the one or more sensors, cause the processor to compare the measured physiological information with a target physiological range associated with blood flow through the aorta such that the catheter controller unit automatically adjusts expansion and contraction of the expandable aortic blood flow regulation device to adjust an amount of blood flow through the aorta if the measured physiological information falls outside the target physiological range.

A system for removing fluid from a urinary tract includes at least one sensor configured to detect signal(s) representative of pulmonary artery pressure and communicate signal(s) representative of the pulmonary artery pressure and a controller. The controller is configured to: receive and process the signal(s) from the at least one sensor to determine if the pulmonary artery pressure is above, below, or at a predetermined value; and provide a control signal, determined at least in part from the pulmonary artery pressure signal(s) received from the at least one sensor, to a negative pressure source to apply negative pressure to a urinary catheter to remove fluid from a urinary tract when the pulmonary artery pressure is above the predetermined value and to cease applying negative pressure when the pulmonary artery pressure is at or below the predetermined value.

A system for removing fluid from a urinary tract includes: at least one sensor configured to detect signal(s) representative of bioelectrical impedance and communicate signal(s) representative of the impedance; and a controller. The controller is configured to: receive and process the signal(s) from the at least one sensor to determine if the impedance is above, below, or at a predetermined value; and provide a control signal, determined at least in part from the signal(s) representative of the impedance received from the at least one sensor, to a negative pressure source to apply negative pressure to a urinary catheter when the impedance is below the predetermined value and to cease applying negative pressure when the impedance is at or above the predetermined value.

Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

A negative-pressure cup structure includes a cup and a vibration generating mechanism. The cup has a chamber. Two ends of the cup are separately formed with an opening end and a closed end. The closed end is provided with a negative-pressure suction hole and an electric connection hole communicating with the chamber. A bar is extended from the closed end and located in the chamber. The vibration generating mechanism includes a box, a vibration member disposed in the box and a power connector electrically connected to the vibration member. The vibration generating mechanism is fixed in the chamber of the cup in a manner of the box and the bar being connected and the power connector being inserted to the electric connection hole. Therefore, the users may obtain a better vibrational sense.