Systems and methods are provided for aerosolizing and delivering therapeutic substances in an electronic aerosol delivery device with airflow regulation. Calibrated airflow resistance settings enable adjustment and control of flow velocity and or flow volume of air, aerosolized air, and or entrained aerosol particles, through the device, for optimal aerosol delivery among diverse conditions and applications.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

Devices and systems with methods for detecting a sealing condition between a patient interface and a patient, and adjusting the patient interface to maintain the patient interface in sealing contact with the patient. The patient interface may include a sealing structure to form a seal on the patient, and a positioning structure to secure the sealing structure to the patient. The patient interface may include a sensor coupled to the sealing structure. A processor determines the sealing condition between the sealing structure and the patient based on a signal from the sensor, and adjusts at least one of the sealing structure and the positioning structure to maintain the sealing structure in sealing contact with the patient. A prediction system predicts a leak between the sealing structure and the patient based on the sensor signal. A learning system learns how to fit the sealing structure to the patient to form a seal.

A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a negative pressure source, a sensor, and a controller. The negative pressure source can provide negative pressure via a fluid flow path to the wound dressing. The sensor can monitor pressure in the fluid flow path. The controller can determine whether the wound dressing is coupled to a wound from a change in magnitude of pressure in the fluid flow path over time being more indicative of a steady state condition than a chaotic condition while the negative pressure source maintains negative pressure in the fluid flow path within a pressure range. In addition, the controller can output a first indication denoting that the wound dressing is coupled to the wound and a second indication denoting that the wound dressing is not coupled to the wound.

An electronic inhaling device for detachably receiving a spray bottle having a bottle body with a spray mouth, includes: a casing formed with a vertical slide slot, in which the spray bottle is adapted to be disposed slidably; a bottle support seat installed in the casing, having a receiving inlet permitting extension of the spray mouth of the bottle body when the spray bottle is seated on the support seat and a discharging outlet in spatial communication with the receiving inlet in order to discharge a volatile substance sprayed out from the spray mouth of the bottle body via the discharging outlet; and a monitoring module disposed in the casing for monitoring movement of the spray mouth relative to the bottle body, counting a discharged number of the volatile substance sprayed out from the spray mouth of the bottle body via the discharging outlet.

Disclosed is an injection gadget corresponding to an end-effector such as a rescue robot or the like. The injection gadget is configured such that an injection needle is disposed inside an injection assembly, an injection liquid is provided between a cylinder and a piston of the injection assembly, and the piston is moved by an elastic force of a spring previously compressed inside the cylinder so that the injection needle protrudes to the outside of the injection assembly and the injection liquid is ejected, and includes a bracket that replaceably mounts the injection assembly, a main body that is connected to the bracket and includes a first body space portion of which one side surface facing the bracket and the other side surface are open to pass through each other and a second body space portion that is disposed next to the first body space portion, a controller that is mounted in the second body space portion, a linear actuator that moves a transfer shaft in accordance with a control signal of the controller, and a pusher that is disposed between the linear actuator and the injection assembly, and transmits a force of the linear actuator toward the injection assembly so that a locking pin of the bracket is deviated from locking guides of the piston of the injection assembly.

A device and method are provided for monitoring access to a patient by a device that withdraws liquid from the patient and/or supplies liquid to the patient, via a flexible line. A vessel access can be monitored during an extracorporeal blood treatment for which the blood of a patient is withdrawn via a flexible arterial line having an arterial puncture cannula, and supplied to the patient via a flexible venous line having a venous puncture cannula. The monitoring device has a line guide for loosely guiding a line segment of the flexible line. By detecting a change in situation of the loosely guided line segment, a conclusion is made as to whether an incorrect vessel access has occurred.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A CPAP compliance notification apparatus for use with a CPAP device having a flow generator, a CPAP hose, and a CPAP mask, the CPAP compliance notification apparatus, including a patient occupancy mat, an air pressure sensor, an air pressure tube, a compliance notification controller unit, a housing, a user interface, a programmable logic controller together with a patient to control parameters of the CPAP compliance notification apparatus in implementing a compliant CPAP treatment to the patient.