The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.

An injection tool and associated methods are shown. Example tools and methods described provide cooling to numb a local area prior to an injection. The local numbing can be used to reduce or eliminate pain associated with the subsequent injection. In selected examples, circuitry and one or more sensors are used to calculate an appropriate contact time of a heat sink with the local region to best provide a desired amount of numbing.

Sleep management apparatus including a wearable device having one or more physiological sensors operably engaged with a body of a user. One or more processors can be communicatively coupled with the wearable device having a memory storing instructions when executed operable to: detect one or more indicators of a bedtime; measure one or more physiological indicators predictive of a ready for sleep condition of the user; suggest, when one or more of the one or more physiological indicators exceed a predetermined threshold, a sleep preparation exercise; and track an effectiveness of the sleep preparation exercise.

Computerized oral prescription administration (COPA) devices, systems, and methods are provided. In one embodiment, a substance dispensing apparatus includes a mouthpiece having a recess sized and shaped to mate with an intended user's dentition; a sensing element coupled to the mouthpiece and configured to determine whether the intended user's dentition is positioned within the recess; and an actuator coupled to the mouthpiece and in communication with the sensing element, the actuator configured to dispense a substance from a reservoir coupled to the mouthpiece in response to the sensing element determining that the intended user's dentition is positioned within the recess.

The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.

Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

The present invention provides a connector for push-connecting a cartridge containing vaporizable material, such as a 510-cartridge, to a power-supplying device. The connector includes a housing containing electrical contacts, a cartridge-receiving end for receiving a conductive end of the cartridge, and a flexible, preferably silicone, ring connected to the cartridge receiving end of the housing for retaining the conductive end of the cartridge inserted therethrough against the electrical contacts. The ring is preferably part of a silicon boot that houses the housing.

Disclosed herein is a breast pump sensor network. The breast pump sensor network includes an emitter disposed within a bodily fluid capture system and a detector disposed within the bodily fluid capture system. Further disclosed is a method for controlling the breast pump sensor network which includes emitting a beam of electromagnetic radiation within a bodily fluid capture system, detecting one or more drops of body fluid within the bodily fluid capture system, determining a bodily fluid flow rate based at least on the detected one or more drops of bodily fluid, and providing the determined bodily fluid flow rate to at least one user.

A smart syringe (200), including a disposable body and a smart cap (250) is provided. The disposable body includes a barrel (210), a stopper (220), and a plunger rod (225) attached to the stopper. The smart cap (250) is configured to be attached to the plunger (225) and comprises a sensor (446) which senses a movement of the plunger rod (225), an indicator (256/460/462), a communication module (458), and a power supply (468). The communication module (458) is configured to communicate with an external device (350). Data output from the sensor (446) may be transmitted to the external device (350) in order to determine a dose provided to a patient. Alternately, a microcontroller (450) in the smart cap (250) may determine an amount of a dose provided to a patient based on data output from the sensor (446), and information of the dose may be transmitted to the external device (350).