Systems, apparatuses, and methods for providing negative pressure with instillation fluids to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, a system may comprise a tissue interface adapted to be coupled to a source of instillation fluid and a dressing interface having a therapy cavity that includes a pH sensor, a humidity sensor, a temperature sensor, and a pressure sensor embodied on a single pad within the dressing interface to provide data indicative of acidity, humidity, temperature and pressure at the tissue site. Such apparatus may further comprise algorithms for processing such data for detecting leakage and blockage conditions as well as providing information relating to the progression of healing of wounds at the tissue site. An illustrative method may comprise disposing the tissue interface at the tissue site and the therapeutic cavity in fluid communication with the tissue interface. The method may further comprise instilling fluid to the therapy cavity and then sensing the pressure, humidity, temperature, and the pH of the fluids adjacent the tissue interface. The method may further comprise determining various flow characteristics of the system by using a processing element electrically coupled to the sensors for transmitting property signals from the sensors to a controller configured to assess the property signals in order to identify the flow characteristics.

A leak may be detected in a heat exchanger of a hemodialysis device. A drain valve is opened by the controller, and then closed by the controller after a pre-selected time period. An initial pressure is determined in the spent dialysate circuit and stored in the memory. A system pressure is determined at periodic time intervals and compared to a pre-determined maximum pressure. The controller then determines whether the heat exchanger has a leak, in that in response to the system pressure exceeding a predetermined maximum pressure, a command is generated to execute an event including suspending a disinfectant operation with a disinfecting agent, and in response to the initial pressure subtracted from the system pressure being greater than a predetermined minimum pressure differential, a command is generated to execute an event including suspending the cleanse operation with the disinfecting agent.

The present invention relates to an auto injector (1) comprising a prefilled liquid medicament container, a hollow auto injector body (2) housing the medicament container. The auto injector body (2) has an elongated part, a first end side (21) and a second end side (22) and at least one through hole (3) arranged between the end sides (21, 22). The through holes (3) allow for flow of gas through the auto injector body (2) when the auto injector body (2) houses the medicament container. The invention further relates to a method comprising inserting the auto injector (1) into the package via an opening in a non-inert environment, and, in a non-inert environment and under atmospheric pressure: replacing the air in the package with inert atmosphere by one or several cycles of removing air and inserting inert gas through the opening, wherein the air and inert gas in part flows through the at least one through hole (3) of the auto injector (1). The method further comprises sealing the opening under vacuum.

A sensor system capable of detecting tissue counter pressure from patients that utilize infusion pumps to administer their medication is provided. Embodiments include a retrofitted piece that is placed between the user's infusion set and pump, as well as a “smart” infusion set configured for measuring characteristics of a fluid traveling therethrough. Hardware is provided that couples with the sensor to store, analyze, and compare data to distinguish between normal and non-normal injection/infusion profiles. An alert system notifies the user of a malfunction within the pump, within the infusion set, or at the injection/infusion site.

A respiratory therapy system for providing continuous positive air pressure (CPAP) to a patient may include a flow generator for generating a supply of breathable gas, a sensor to measure a physical quantity while the breathable gas is supplied, and a computing device. The computing device may be configured to: receive sensor data that is based on measured physical property of the supply of breathable gas; control the flow generator to adjust a property of the supply of breathable gas; display a question and a plurality of selectable responses; receive a first input selecting one of the selectable responses; and display a coaching response corresponding to the selected response.

An inline microgravity air trap device includes an elongate air trap chamber, the air trap chamber having a blind end, an opposite air outlet end containing a gas egress opening, a fluid inlet port connecting to a pressurized fluid supply, a fluid outlet port connecting the air trap chamber to a fluid delivery destination, a filter forming a tube having an interior, a first end at the blind end of the air trap chamber and a second end at the gas egress opening, and a structural insert in the interior of the tube, having a first insert end located at the blind end, and a second insert end located the air outlet end, where the chamber is formed to direct fluid from the pressurized fluid supply to accelerate centrifugally around the filter, forcing gas contained in the fluid to pass through the filter into the interior of the tube.

A negative pressure wound therapy system can include a negative pressure source configured to provide, via a fluid flow path, negative pressure to a wound covered by a wound dressing. The system can include a controller. The controller can be configured to periodically activate the negative pressure source to maintain negative pressure in the fluid flow path between a low negative pressure setpoint and a high negative pressure setpoint. The controller can be configured to determine a change in a volume of the wound based on a difference between a first time and a second time at which the high negative pressure setpoint has been established in the fluid flow path, the second time being subsequent to the first time. The controller can be configured to provide indication of the change in the volume of the wound.

Apparatus and methods provide system characterisation such as for operation of respiratory treatment apparatus. Such a characterisation may include a determination of a patient interface type and/or an event such as a leak or blocked vent. For a characterisation, one or more controller(s) or processor(s) may be configured to make a determination of parameters that best fit a template curve, such as a quadratic function, to a plurality of measurements, such as data points. Each data point may include a pressure value, and a flow rate value at the pressure value. Parameters from the function may then be applied, such as with a data structure to characterize the system, such as with an identification of the patient interface type from the parameters. In some versions, parameter(s) of operation of the apparatus may be adjusted based on the characterisation, such as by using the parameters of the template.

Methods and apparatus, such as a controller of a respiratory therapy device, generate a signal representing an estimate of flow rate of gas flow from the device. The respiratory therapy device may include a motor-operated blower. The method may include receiving in the controller, signals generated by a set of sensors, including measures of pressure and frequency (e.g., speed) of the motor. The controller may be configured to compute an entrained air density function and generate the estimate signal based on a function of the measures of pressure and frequency, and the entrained air density function. The entrained air density function may apply signals from additional sensors, such as atmospheric pressure, gas temperature, and ambient relative humidity, to compute atmospheric density. Control operations of the therapy device may then be based on the estimated signal, which may be applied to assess accuracy of a signal from a flow sensor.

A cartridge to be used for adsorption dialysis. A container having flexible walls are arranged to provide an inner space enclosing adsorption powder, comprising activated carbon, a phosphate adsorbent and a potassium ion adsorbent and other adsorbents. A sufficient amount of activated carbon is provided for adsorption of urea by the activated carbon. The cartridge forms a vacuum-packed transportation cartridge by generating a sub-pressure in the inner space, whereby the powder particles are immobilized and the cartridge becomes stiff. Before use, the cartridge is primed by introducing a liquid into the inner space, which introduction takes place at a low pressure. During use, dialysis solution is circulated through the cartridge, which is still exposed to a sub-pressure, whereby the flexible walls are sucked against the powder material. A peritoneal dialysis circuit comprises a filter, in which a primary circuit is formed with the filter and the peritoneal cavity and a secondary circuit is formed with the filter and the adsorbent cartridge.