A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.

Disclosed is an NO supply device including a main gas circuit to convey an NO/N.sub.2 mixture to a main output orifice which is designed to supply the inspiratory branch of a medical ventilator; and a backup circuit including a backup NO circuit including a backup NO line which is supplied with NO/N.sub.2 mixture, and a backup O.sub.2 circuit includes a main O.sub.2 line which is connected fluidically to the backup NO line in order to form a common line in fluid communication with a secondary output which supplies an NO/N.sub.2/O.sub.2 mixture designed to supply a manual breathing bag.

Disclosed is an NO supply device including a main gas circuit with NO/N.sub.2 flowrate controller controlled by piloting unit, and a backup circuit including a backup NO circuit and a backup O.sub.2 circuit. The piloting unit are configured in particular to control the NO/N.sub.2 flowrate controller in such a way as to regulate the flowrate of NO/N.sub.2 mixture in the main gas circuit and to direct the gaseous flow obtained in a downstream portion of the backup NO circuit connecting to the backup O.sub.2 circuit in order to form a common backup line including a backup outlet.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject.

An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.

Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

A ventilator system including an oxygen delivery cylinder, an air delivery unit, connecting tubes, and a digital display unit. The system further includes a Y connector configured to mix air and oxygen, to form a gas and pass said gas towards an outlet of the system. A water manometer that is configured to monitor a pressure of the gas in the system and blow off the excess pressure of the gas. A solenoid valve that is configured to adjust an end respiratory pressure obtained from a breathing device connected to the outlet of the system. The pressure of the gas being instantly delivered to the breathing device is measured by water manometer from a dead space near the outlet, thereby enabling a dual monitoring of the gas pressure being delivered to the breathing device.