A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiO.sub.x composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O.sub.3SiC covalent bonding, as a proportion of the O.sub.3SiC covalent bonding plus SiO.sub.4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO.sub.4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

The present invention relates to an injection assistance device including a body with a needle, grasping arrangement and first elastic return arrangement to dampen limited movement of the grasping arrangement, in at least one of the two directions, respectively distal or proximal, during an injection phase, and to maintain the body in its insertion position and the needle at a constant insertion length during the injection step, when the user increases, respectively releases, a distal pressure on the grasping arrangement. The invention also relates to an injection set including an injection device and the assistance device.

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

Systems and methods are disclosed that include providing a syringe with an enhanced needle, at least part of which is subjected to a treatment that enhances the performance of the needle. The treatment is administering at least a portion of the needle by projecting a heated, ionized airflow over the at least a portion of the needle at a temperature of at least 225 F. to not greater than 325 F. for not greater than 1 second. The treatment reduces a post-draw needle penetration force of the needle as compared to a traditional untreated needle, enhances lubrication adherence to the needle, and reduces residual metallic particle contamination resulting from the manufacturing process when compared to a traditional needle that has not been subjected to a surface treatment, which result in a significant reduction in the pain patient may experience during an injection.

A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area c.sub.1 with an outer radius r.sub.1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain value for r.sub.1.

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiO.sub.x composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O.sub.3SiC covalent bonding, as a proportion of the O.sub.3SiC covalent bonding plus SiO.sub.4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO.sub.4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.

A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area c.sub.1 with an outer radius r.sub.1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain minimum value the radius of curvature.

An infusion device configured to implant a cannula and a sensor in a user. The infusion device includes a first unit defining a first housing and a second unit defining a second housing. The second housing is configured to engage the first housing. The infusion device includes a first insertion needle configured to implant the cannula in the user and a second insertion needle configured to implant the sensor in the user when the second unit engages the first unit. The infusion device includes processing circuitry in electrical communication with the sensor and a fluid reservoir in fluid communication with the cannula. In examples, the first unit and the second unit are configured to engage using an inserter.

A safety device for a syringe including a connector which can be coupled to a syringe, a main body provided with a cavity and which can be coupled to the connector so as to extend above it and a needle body for supporting and housing a needle or cannula, the needle body longitudinally extending in the connector and in the main body. The device further includes a push element which can be coupled to a distal end of the needle body and movable inside the connector by action of an axial thrust of a plunger of the syringe, and a needle support which can be coupled to the needle body and is operable by the push element between a locked position of the needle body, wherein the needle support is interposed between the connector and the needle body, and an unlocked position of the needle body.