A therapeutic product delivery device is described which comprises a device body and a cartridge for holding a therapeutic product. An engagement structure is provided for releasably engaging the cartridge with the device body. A fault detector is provided for detecting a fault in the delivery of the therapeutic product from the cartridge. A release trigger is responsive to the detection of a fault to cause the engagement structure to release the cartridge from the device body. In this way, a fault causes the cartridge to be released from the device body, which will prevent any further delivery of the therapeutic product to the patient. This solution is strongly preferable to a solution in which a product delivery mechanism (e.g. a pump) is merely paused or stopped, since when the cartridge separates then no further delivery is possible at all, until the cartridge is reattached (or more probably replaced with a new cartridge in case the fault is with the cartridge).

Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

A dialysis concentrate production assembly for producing a dialysis concentrate liquid by dissolving a dry concentrate in water. The dialysis concentrate production assembly includes a mobile interchangeable container which contains the dry concentrate and a stationary production system. The mobile interchangeable container includes an outlet port and a combined port. The stationary production system is fluidically connected to the outlet port and to the combined port via coupling assemblies via which the dry concentrate is mixed with the water to form the liquid dialysis concentrate. At least one coupling assembly includes a system-side coupling body with a liquid line connector having a non-circular cross-section, and a container-side coupling body with a liquid line socket having a non-circular cross-section which is complementary to the non-circular cross section of the liquid line connector. The liquid line connector and the liquid line socket can be plugged together in only one single rotational position.

A refill assembly for use in a medicinal inhaler, the refill assembly being configured to be removably coupled to a reusable assembly of a medicinal inhaler, the refill assembly comprising: a patient port; a canister actuable by the reusable assembly to deliver a dose of medicament to the patient port, a sleeve which is selectively actuable by a user independently of the reusable assembly so as to act on the canister to deliver a dose of medicament, the sleeve having a first position in which the sleeve cannot be actuated to cause a dose of medicament to be released from the canister and a second position in which the sleeve is actuable to cause a dose of medicament to be delivered to the patient port; the refill assembly further comprising: an override element which engages the sleeve, the override element being moveable from a first position in which the sleeve is retained in its first position by the override element and a second position in which the sleeve is permitted to move to its second position upon depression of the sleeve by a user.

Technologies (e.g., devices, systems and methods) for sanitizing reservoirs are described. In some embodiments, the technologies include a sanitization gas system and a connector unit or a hole in the reservoir wall, configured to connect a supply line to the reservoir. The connector unit may include an inlet passageway for supplying sanitizing gas (e.g., ozone) into the reservoir.

The hemodialysis system includes a closed loop dialysate flow path which includes a dialyzer and a reservoir for storing dialysate, and a closed loop blood flow path which passes through the dialyzer in the opposite direction as the dialysate flow path. In addition, the hemodialysis system includes pumps for pumping dialysate and blood through their respective flow paths, a flow sensor for measuring the flow rate of dialysate in the dialysate flow path, and a level sensor for measuring the level of dialysate in the dialysate reservoir. A processor is connected to the flow sensor, reservoir level sensor and pumps to provide a first closed loop control system including the processor, flow sensor and a first dialysate pump, and a second closed loop control system including the processor, level sensor and a second dialysate pump which enable the processor to initiate, monitor and maintain ultrafiltration.

According to an aspect, there is provided a training device for use in an inhaler, the training device comprising a body that is configured to be received at a first position in a housing of an inhaler, wherein the body comprises an interface arranged to connect to a canister interface in the housing of the inhaler; an electrical circuit configured to perform one or more functions; and a circuit triggering mechanism that comprises a switch for enabling the electrical circuit to perform the one or more functions when the switch is closed, wherein the circuit triggering mechanism is configured such that the switch is closed when the body is pressed from the first position towards the canister interface and into a second position in the housing of the inhaler.

Security features for an electronic metered-dose smart inhaler, mobile app, and cloud-based software system for use with medical prescriptions and clinical trial regimens. The smart inhaler requires several types of user validation and feedback, and enters a locked-out state when required user feedback is not received or when received user feedback raises a suspicion of fraudulent or improper use. While the smart inhaler system is well suited for aerosol medical marijuana products, it may be used to deliver and conduct clinical trials on any type of product suitable for aerosol administration including other types of medication and non-medical products, such as nicotine, herbal products, pain killers, sleep aids, dietary stimulants, dietary suppressants, etc. The security features are not limited to aerosol inhalers, and may be applied more widely to other types of in-home, patient-administered products.

In some embodiments, an apparatus includes a housing defining an interior space, a sensor, and a processor. The sensor is configured to sense an indication generated by a compute device. The indication can be at least one of a visual indication, an auditory indication, or a vibratory indication. The processor can be configured to determine whether to transition a lock status of the apparatus from locked to unlocked based on the indication sensed by the sensor. The processor can initiate a transition of the lock status from locked to unlocked upon determining to transition the lock status.

The e-vaping device includes a first housing, a chamber defined within the first housing, a first structure and a second structure that interface with the chamber, the first structure is configured to accept at least one first-type consumable within the chamber and the second structure is configured to receive at least one second-type consumable within the chamber.