A healthcare enterprise has an associated management resource that manages operation of one or more medical devices in the healthcare enterprise. To determine what functionality to enable in a respective medical device, the respective medical device establishes a communication link to communicate in a network environment. Subsequent to establishing the communication link, the medical device initiates communications over the communication link from the medical device to the remotely located management resource. The communications include a unique identifier value assigned to the medical device. Depending upon feedback (such as granting or denial of authorization) from the management resource with respect to the unique identifier value, the medical device operates in one of multiple different operational modes such as a fully functional mode or a reduced functionality mode.

Some embodiments an infusion pump system can be configured to activate an alarm in response to a calculated prediction of the user's future blood glucose levels. Optionally, the predictive calculation of the user's future blood glucose levels can be based at least in part upon a recent blood glucose level, a trend of blood glucose levels over time, and an insulin load of the user.

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. The long term sensitivity drift of catalytic type electrochemical gas sensors may be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used to reduce the amount of times the sensor goes offline.

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. The long term sensitivity drift of catalytic type electrochemical gas sensors may be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used to reduce the amount of times the sensor goes offline.

A dialysis concentrate production assembly for producing a dialysis concentrate liquid by dissolving a dry concentrate in water. The dialysis concentrate production assembly includes a mobile interchangeable container which contains the dry concentrate and a stationary production system. The mobile interchangeable container includes an outlet port and a combined port. The stationary production system is fluidically connected to the outlet port and to the combined port via coupling assemblies via which the dry concentrate is mixed with the water to form the liquid dialysis concentrate. At least one coupling assembly includes a system-side coupling body with a liquid line connector having a non-circular cross-section, and a container-side coupling body with a liquid line socket having a non-circular cross-section which is complementary to the non-circular cross section of the liquid line connector. The liquid line connector and the liquid line socket can be plugged together in only one single rotational position.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.

The pharmaceutical injection device of the present invention comprises a cartridge holder, a main case, a piston, a motor, an opening component, an open/closed detection switch, and a controller. The motor drives the piston in either an insertion direction in which the piston is inserted into a pharmaceutical cartridge, or a pull-out direction in which the piston is pulled out of the pharmaceutical cartridge. The opening component opens the cartridge holder in conjunction with the movement of the piston in the pull-out direction. The open/closed detection switch detects whether the cartridge holder is open or closed. When the open/closed detection switch detects that the cartridge holder is open, the controller controls the motor so as to stop the piston.

Some embodiments of an infusion pump system may be configured to provide a desired level of resistance to liquid ingress to the pump casing while contemporaneously providing air transmissibility for equalization of air pressure differentials between the interior and exterior of the pump casing. Further, some embodiments can detect when moisture inside a casing of the infusion pump system is greater than or equal to a threshold level and can initiate one or more patient safety countermeasures.

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used reduce the amount of times the sensor goes offline. Systems and methods described may factor in actions occurring at the delivery system and/or aspects of the surrounding environment, prior to performing a baseline calibration, and may postpone the calibration and/or rejected using the sensor's output for the calibration.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.