A build-plate with integrally-formed spinal implant constructs and a method used in forming spinal implant constructs on the build-plate and machining the spinal implant constructs formed on the build-plate to manufacture spinal implants is provided. The spinal implant constructs can be formed via additive manufacturing processes by adding material to an upper surface of the build-plate, and then the spinal implant constructs can be subjected to subtractive manufacturing processes to form the spinal implants.

A composite implant device for use in a medical application, comprising a synthetically-derived mesh that mimics particular critical aspects of a biologically-derived mesh. The composite implant device can be used for the reinforcement and reconstruction of tissues within the body and can be comprised of a majority of synthetic components and minority of naturally-derived components which mimic the structure and function of a naturally-derived mesh.

A method for producing a tailor-made implant intended to be implanted at an implantation site of a damaged bone part, the method comprising a step in which a 3D representation of a standard implant is superposed on a 3D representation of a damaged bone part by positioning said standard implant on an implantation site of the damaged bone part, in order, if necessary, to modify the dimensions and/or to adjust the shape of said standard implant, and also, if necessary, to modify the outer surface of said standard implant, which may be either the impression or substantially the impression of the outer surface of said bone part in the state prior to superpositioning of said implant, when the geometry of the damaged bone part is intended to be retained, or a functional outer surface, when said tailor-made implant is intended to be used at the interface of two bone parts cooperating with each other.

An ablatable corneal inlay for correction of refractive errors and/or presbyopia, and a method of correcting refractive errors and presbyopia in an eye of a patient using an ablatable corneal inlay is disclosed herein.

A flexible prosthetic inner socket that resides inside of a rigid prosthetic socket that is fabricated by forming a sized, injection molded, flexible inner pre-socket. The flexible inner pre-socket includes a body formed with an opening and an enclosed end. The Pre-socket can be heated and stretched over a prosthetic residual limb model and then a prosthetic rigid socket can be formed over it. It can also be heated and vacuum-formed inside of an existing hard prosthetic socket in order to provide global volume reduction intended to make the rigid prosthetic socket fit tighter onto the residual limb. The opening of the flexible inner socket may be trimmed after the formation to fit contours of an opening of the rigid prosthetic socket.

Materials and methods for cell-mimetics having mechanical properties of biological neural axons are provided. A cell-mimetic device includes an array of fibers comprised of hexanediol diacrylate (HDDA) or an HDDA derivative, and at least one derivative of polyethylene glycol (PEG) selected from the group consisting of: PEG-acrylate, PEG-diacrylate, and any multi-arm PEG-acrylate.

This patent application claims the use of directed energy in the form of electronically scanned ion beams to form plastic parts by selectively curing commodity or engineering resin in the shape of the part. Polymerization is limited to the vicinity of the controlled Bragg-peak of the ion beam (i.e., where linear energy transfer is maximized), if necessary, by the use of chemical polymerization inhibitors or conditions that inhibit polymerization.

The present application relates to a composition, which comprises: (a) a photopolymerizable substance; (b) a thiol; (c) a photoinitiator; (d) a thermosensitive polymer; and (e) water, and can be used as a bio-ink for preparing a bio-hydrogel for direct-writing 3D printing. The present invention further relates to a method for preparing the composition, and a direct-writing 3D printing method using the composition.

A method includes identifying first geometry of a first mold associated with a first dental arch and a second geometry of a second mold associated with a second dental arch. The method further includes determining, based on the first geometry and the second geometry that the first mold and the second mold are to be used for simultaneous forming of a first dental appliance and a second dental appliance on a plate in a dental appliance manufacturing system. The method further includes causing, based on the first geometry and the second geometry, one or more portions of the dental appliance manufacturing system to be configured to form the first dental appliance and the second dental appliance.

An in-situ additive-manufacturing system for growing an implant in-situ for a patient. The system has a multi-nozzle dispensing subsystem and a distal control arm. The multi-nozzle dispensing subsystem in one embodiment includes first and second dispensing nozzles. The first and second nozzles include first and second printing-material delivery channels, respectively. In another embodiment, the in-situ additive-manufacturing system includes a multi-material subsystem having a dispensing nozzle including first and second printing material delivery channels. Controlling computing and robotics componentry are provided. In various aspects, respective storage for first and second printing materials, and one or more pumping structures, are provided.