A method of manufacturing an implant is disclosed. The method includes preparing a wax template assembly based upon anatomical characteristics of an implantation site. Post formation of the template assembly, a lamination layer is provided over the template assembly resulting in a laminated template assembly. The lamination layer is composed of at least one polymer dissolved in one or more solvents. One or more coating layers of a pre-defined coating material are provided over the laminated template assembly to prepare a mold. The mold may then be sand-rained to form a sand coated mold. The sand coated mold may be de-waxed and baked for melting out the template assembly to form a de-waxed mold. A casting material is then poured over the de-waxed mold to form a casted mold which is cooled and solidified to form a casted implant which is further heat treated and finished to form the implant.

The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

The invention relates to a method for manufacturing a breast prosthesis, in which a first dispersion of a first granular material is introduced into a cross-linkable silicone compound. The silicone compound subsequently is cured in order to form a prosthesis body, wherein the prosthesis body is heated to a shrinking temperature which lies above the melting point of the thermoplastic material.

A method is provided for manufacturing a complex hollow article from a flexible polymer material. The method includes using an additive manufacturing system to form a precursory structure that is formed from a build material and phase change material, melting and removing the phase change material, injecting uncured liquid flexible polymer material into a cavity defined by the build material, curing and solidifying the flexible polymer material, and cracking and removing the build material from the flexible polymer material to provide the hollow article.

Systems, methods, and devices for improved orthodontic treatment of a patient's teeth are provided herein. A method may include determining a movement path to move one or more teeth from an initial arrangement to a target arrangement, determining an appliance geometry for an orthodontic appliance comprising a shell and one or more integrally formed components, wherein the shell comprises a plurality of teeth receiving cavities shaped to move the one or more teeth from the initial arrangement to the target arrangement, and generating instructions for direct fabrication of the orthodontic appliance, wherein the instructions are configured to cause direct fabrication of the shell using a first material and direct fabrication of the one or more integrally formed components using a second, different material.

Intraocular implants and methods of making intraocular implants are provided. The intraocular implant can include a lens body having a lens material and a mask having a mask material. The lens body can be secured to the mask. The mask material can include a modulus of elasticity that is greater than or equal to a modulus of elasticity of the lens material.

Some embodiments relate to additive manufactured articles having coated surfaces and related methods. The methods may comprise forming a three-dimensional (3D) article by additive manufacturing to obtain an additive manufactured 3D article having a monolithic structure that is not capable of construction by machining, and exposing the additive manufactured 3D article to one or more precursor gases to form a coating layer on a surface of the additive manufactured 3D article. The additive manufactured articles may comprise an additive manufactured three-dimensional (3D) body. The additive manufactured 3D body may have a monolithic structure that is not capable of construction by machining. The additive manufactured 3D body may have a coating layer on a surface of the additive manufactured 3D body.

One aspect of the present disclosure relates to a tissue integration device. The tissue integration device can be produced by forming a polymer mixture into a shape. The polymer mixture can include a polymer resin and a growth-promoting medium. Next, at least one polymer forming the polymer resin can be oriented in at least one direction. The shaped polymeric material can then be formed into the tissue integration device.

A dental restoration apparatus that eliminates time-consuming, labor-intensive steps conventionally needed to fabricate molds, and thereby facilitates dental restorations in a shorter time, while reducing the discomfort and embarrassment sometimes associated with provisional restorations, which includes an additive manufacturing apparatus (e.g., a 3-D printer) having a tool head (e.g., a print head) and a fixture for controlling the position of the tool head relative to the teeth of a patient, allowing fabrication of a planned dental structure directly on an existing dental structure.

A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.