The present invention relates to a microneedle comprising a plurality of portions, wherein the plurality of portions comprise a distal end portion and a proximal end portion, at least two of the plurality of portions are made of different polymers, and the distal end portion is made of at least one polymer with high swellability and high viscoelasticity.

A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.

To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy.

Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 μm≦L2≦L−L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is μm.

The manufacturing method of the sheet having the needle-like protruding portions includes: preparing a mold including needle-like recessed portions, and a solution supply device including a slit-like opening formed at a nozzle distal end portion; supplying a solution from the solution supply device to the mold in a state that the nozzle distal end portion is pressed to a front surface of the mold, and filling the solution in the needle-like recessed portions; and moving the solution supply device relatively to the mold in a state that the nozzle distal end portion is brought into contact with the front surface of the mold, and, as a hardness distribution in a thickness direction of the mold, an average value of a Young's modulus at a part within 40 μm from the front surface of the mold is 1.9 MPa or higher and 100 MPa or lower.

Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

The invention relates to a medical injection device having polymeric housing. The housing comprises a moulded outer housing element and a moulded ring-shaped unitary element. The ring-shaped unitary element carries a pointer and a thread segment in predetermined and correlated positions. The pointer points to indicia on a scale drum and the thread segments guides the scale drum. The outer housing element is moulded over the unitary element to form one single component.

A transdermal administration device including an administering part including a substrate having a first surface, and at least one projection protruding from the first surface. The projection has a shape which extends along the first surface and includes one linear top edge which is located away from the first surface and has a first end and a second end, two primary lateral faces which share the one linear top edge and have lateral edges each individually connecting the first surface with the first end, and a secondary lateral face which has the lateral edges in common with the respective two primary lateral faces and forms one corner together with the two primary lateral faces. One of the lateral edge and the top edge on the primary lateral face form an obtuse angle, and the two lateral edges on the secondary lateral face form an acute angle.

A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.

A dispensing outlet includes a housing with a first end of the housing having a first outlet and a second end of the housing having a mixing or reception space. The mixing or reception space is configured to receive a further component, and a pre-determined breaking point is formed between the first outlet and the mixing or reception space.