Various embodiments of a device, a kit and method for delivering a drug depot are disclosed. The device comprises a housing including a lower body, an upper body, a ring member; and a drug cartridge. The lower body defines a lower body channel. The upper body defines an upper body channel. The drug cartridge defines a depot channel. The ring member is disposed extending upward from an annular step surface of the lower body toward a housing upper end. The ring member includes indicia indicating a characteristic of one or more drug depots in the drug cartridge. A plunger has a push rod for expelling the drug depot through the cannula to a site in the patient. A kit comprises the above components. A method includes assembling the components including selecting a ring member having indicia corresponding to one or more drug depots in the drug cartridge.

A pumping system (200) for controlling the flow of interatrial blood comprises, housed inside a container (201), a control element (30, 30′, 30″) of the interatrial blood flow. The control element comprises: at least one worm screw (31), the rotation of which creates a two-way flow of interatrial blood; or a pair of counter-rotating propellers (31′); or a pair of membranes (31″) whose deformation creates a two-way flow of interatrial blood; or a flexible structure (31″) whose change in volume within the container (201) creates a two-way flow of interatrial blood.

Provided is a treatment method and a medical device that can intentionally and locally administer a drug to a lesion area appearing in a narrow blood vessel such as a retinal blood vessel and a spinal blood vessel. The treatment method has an introduction step of introducing a medical elongated body having a drug holder for holding a drug into a living body, an arrangement step of arranging the drug holder at a treatment target inside the living body, and a discharge step of discharging the drug to the treatment target by releasing the drug held by the drug holder.

A method and apparatus are disclosed for an optimized transseptal procedure for providing left heart access, that reduces the number of devices that are used in order to minimize procedural time, complexity and cost. The apparatus comprises a hybrid dilator that comprises the combined functionality of a transseptal sheath and dilator assembly. The hybrid dilator comprises: a dilator shaft defining a lumen for receiving a crossing device therethrough, the dilator shaft being structured to provide support for the crossing device when the crossing device is used to create a puncture in a tissue; and a distal tip having an outer diameter which tapers down to an outer diameter of the crossing device for providing a smooth transition between the crossing device and the distal tip when the crossing device is inserted through the lumen and protrudes beyond the distal tip.

This disclosure relates to methods and apparatus for treating diseases and conditions of the colon and alimentary canal which are associated with obligate anaerobic microorganisms, and particularly, for treating Clostridioides difficile infection. The method and apparatus provide for continuous administration of intraluminal oxygen to the rectum, colon, and cecum to maintain oxygen in those environments at levels toxic to obligate anaerobic microorganisms such as Clostridioides difficile.

The invention provides an introducer assembly for delivering a blood pump into vasculature of a subject, as well as a method for utilizing the assembly.

A biologics delivery device and method of use for promoting angiogenesis in occluded vessels and ischemic tissue of a patient are provided, wherein the biologics delivery device includes a catheter having a proximal end, a distal region having a distal end, and a side wall defining a catheter lumen; an expandable member disposed in the distal region, the expandable member configured to support a subintimal space in an occluded blood vessel of a patient, and to transition between a collapsed state and an expanded state; and a hollow needle having a penetration tip deployable from inside the catheter lumen to outside the catheter lumen, and into tissue surrounding the occluded blood vessel, wherein the expandable member in the expanded state allows the flow of oxygenated blood to the occluded blood vessel. Methods of using the inventive biologics delivery device also are provided to deposit the biologic from a subintimal space to tissue surrounding the occluded blood vessel.

Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

This disclosure provides apparatus and methods for detecting pressure changes within a cavity of a patient. A pressure-sensing catheter comprises an elongate member and a monitor lumen. The pressure-sensing catheter may have a hollow pressure-compliant member in fluid communication with the monitor lumen and thereby define a fluid column. A connector apparatus can be in fluid communication with the monitor lumen, and can comprise a first complementary connector and a second complementary connector. One of the first complementary connector and the second complementary connector can have a pressurizing device that can displace a volume of fluid located within a bore of the other complementary connector into the fluid column, wherein the ratio of the volume of displaced fluid to the volume of the fluid column ranges from about 1:2 to about 1:4. The pressure catheter can comprise a radio-opaque band circumscribing the exterior of the elongate member.

Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. In one embodiment, an indwelling catheter can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter can include first and second restrictors each configured to at least partially occlude the vein within which the catheter is implanted and thus to restrict fluid flow within the vein when the restrictors are activated. The restrictors can each be configured to move between an activated configuration, in which the restrictor occludes the vein, and a relaxed configuration, in which the restrictor does not occlude the vein. The catheter can include a pump, such as an axial motor pump, configured to pump fluid through the catheter.