An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A traumatic brain injury (“TBI”) guideline system employing a patient monitoring sensor (30) and a patient monitoring device (10). In operation, the patient monitoring sensor (30) generates data for monitoring a TBI parameter of a patient (e.g., systolic blood pressure, blood oxygen saturation or carbon dioxide expiration of the patient), and the patient monitoring device (10) generates a TBI indicator derived from a comparison of the TBI parameter data to parameter guideline data associated with a poten -tial TBI of the patient. The patient monitoring device (10) may include a patient data monitor module (17a) to monitor the TBI parameter data, and a TBI monitor module (17b) to generate the TBI indicator. The TBI indicator is informative of a TBI status of the patient (e.g., a hypotension status, a hypoxia status or a ventilation status of the patient), and/or a TBI treatment for the patient (e.g., a ventilation treatment for the patient).

A vaporizing assembly for an aerosol-generating system may comprise a delivery device and a heater assembly. The heater assembly may comprise a heat resistive substrate and a heating element. The delivery device is configured to deliver an aerosol-forming substrate to at least a surface of the heat resistive substrate, wherein the heating element is isolated or separated from the aerosol-forming substrate by the heat resistive substrate. The present disclosure is also directed to a method for generating an aerosol.

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

An activation assembly for a medicament delivery device is presented having a delivery member cover provided with legs and configured to be biased in a proximal direction, a movable sleeve configured to be received between the legs, and an activation sleeve configured to be biased in the proximal direction, wherein the delivery member cover is configured to be moved in an axial direction between a first position and a second position, wherein movement of the delivery member cover from the first position to the second position causes movement of the movable sleeve from a first movable sleeve position to a second movable sleeve position. The delivery member cover axially displaces the activation sleeve in a distal direction when the delivery member cover moves towards the second position, thereby causing a first actuation of a sensor. The activation sleeve is configured to move in the proximal direction when the delivery member cover returns from the second position to the first position, thereby providing a second actuation of the sensor.

A respiratory interface (100) for delivering gases to a single nare of a patient; comprises of a gases delivery assembly having a single sealing nasal prong (200) configured to seal with one of the nares of a patient, a conduit (300), a conduit connector (400) and a support (500) with headgear strap clips (503). The prong slides relative to the support to be interchangeable such that it can engage and seal with either nari. A cuff (250, 1250) is connected to slider members (501, 1501). In another embodiment (FIGS. 33-49), the headgear strap (2600) is coupled directly to the prong; the strap (2600) is received between includes cutouts (2241) of the prong (2200) and a cuff (2250).

This aerosol supply device is provided with: an accommodating section (cartridge) that accommodates a liquid; an atomizing unit that atomizes the liquid to generate an aerosol; and an atomizing amount adjusting unit (gyro sensor and control unit) that adjusts the atomizing amount of the atomizing unit. The aerosol supply device is characterized in that the atomizing amount adjusting unit (gyro sensor and control unit) stabilizes the atomizing amount regardless of the inclination of the aerosol supply device within at least a certain range.

A precision syringe plunger includes a plunger rod and a separately manufactured plunger arm. The plunger rod includes a base formed at a proximal end of the plunger rod and a first interference fit connector formed below the base. The plunger rod is configured to extend longitudinally into a syringe barrel. The plunger arm includes a second interference fit connector formed at a proximal end of the plunger arm. The second interference fit connector is configured to be irreversibly coupled to the first interference fit connector so that the plunger arm extends longitudinally along an outer surface of the syringe barrel. The plunger arm further includes a distally located projection. The projection is configured to receive an applied force that causes an entirety of the syringe plunger to move relative to the syringe barrel so that the plunger rod is actuated through a portion of the syringe barrel.

An aerosol-generating system is provided, including: a cartridge including a storage compartment configured to contain a liquid composition including an aerosol-forming substrate; an aerosol-generating device configured to receive the cartridge and including a power supply and control electronics operably coupled to the power supply; a light source operably coupled to the control electronics and positioned and oriented to emit light into the storage compartment, light emitted from the source is absorbed by the liquid composition; and a detector operably coupled to the control electronics and positioned and oriented to detect light emitted from the source, the source and the detector are both located adjacent to a same side of the storage compartment, and a surface of the storage compartment opposite the source is configured to absorb light emitted into the storage compartment from the source.

An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.