Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

System and methods for analyzing the contents of a fluid canister are provided for use in healthcare settings. The system includes optical and weight sensors to analyze the canister contents.

A respiratory apparatus evaluates accuracy of a pressure sensor, such as when only a single pressure sensor is provided. The accuracy of the pressure sensor may be assessed based on pressure measurement obtained from the pressure sensor and a subordinate or secondary characteristic of the respiratory device such as altitude or atmospheric pressure. A controller or processor may calculate the altitude of the respiratory device based in part on the pressure measurement. In some embodiments, the assessment of the pressure sensor may involve an evaluation of the calculated altitude. In some cases, the assessment of the pressure sensor may involve determining an estimated pressure based on a calculated altitude, and comparing the pressure measurement obtained from the pressure sensor with the estimated pressure.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location.

Disclosed are methods and corresponding systems and devices for providing an estimation model for use with one or more instances of a particular sensor. In some aspects, an estimation model usable for estimating a value of a physiological condition is determined based at least in part on simulated measurements. The simulated measurements are generated for a first sensor, through applying a translation model to convert historical measurements associated with a second sensor into measurements that would have been produced by the first sensor. The second sensor has a different design or configuration than the first sensor. The historical measurements represent changes in the physiological condition as observed by different instances of the second sensor. The estimation model can be made available to one or more electronic devices, including at least one device configured to apply the estimation model to a measurement from a corresponding instance of the first sensor.

A phacoemulsification system includes a pump and a processor. The pump includes: (i) a first chamber having a first volume and configured to flow a first fluid at a first flow rate, between a first reservoir and an eye of a patient, and (ii) a second chamber having a second volume and configured to flow a second fluid at a second flow rate, between a second reservoir and the eye. The processor is configured to control the pump to: (i) set a first flow rate of the first fluid in the first volume, so as to obtain a predefined intra-ocular pressure (IOP) in the eye, (ii) based on the first and second volumes and on the first flow rate, calculate a second flow rate of the second fluid that maintains the predefined IOP constant, and (iii) set the calculated second flow rate to the second fluid.

A method that includes receiving, in a medication delivery module, a command to start a medication delivery from a first control module coupled to the medication delivery module, is provided. The command to start the medication delivery is based on clinical information received at the first control module. The method includes recording, in a memory of the medication delivery module, an update of the medication delivery, receiving an indication that the medication delivery module was decoupled from the first control module, and receiving an indication that the medication delivery module has become coupled with a second control module. The method also includes communicating, in response, with the second control module, to update the clinical information. A system and a non-transitory, computer readable medium storing instructions to perform the above method are also provided.

A filling aid. The filling aid includes a needle housing portion including at least one tab having a starting position and a filling position, and a filling needle cradle including a filling needle, the filling needle cradle slidable connected to the needle housing portion and having a starting position and a filling position, wherein when the at least one tab on the needle housing moves from a starting position to a filling position, the filling needle cradle slides from a starting position to a filling position, and wherein when the at least one tab on the needle housing moves from a filling position to a starting position, the filling needle cradle slides from a filling position to a starting position.

The present invention relates to a testing device for testing the moving force of a plunger of a syringe, comprising a fixture, FX, (3) for holding a syringe (8) in the testing device, TD, (1) for moving force testing, wherein the fixture (3) comprises an annular holding element, AHE, (5) for holding part of the syringe (8), and a support frame, SF, (30) having a support plate, SP, (300) for supporting the annular holding element, AHE, (5), wherein the annular holding element, AHE, (5) is detachably connected to the support plate, SP, (300) via an indirect connection via at least one intermediate element, IE, (10) between the at least one annular holding element, AHE, (5) and the support plate, SP, (300), wherein one intermediate element, IE, (10) is a tempering cylinder, TC, (7) for tempering at least part of the syringe (8). The invention further relates to a method for testing the moving force of a plunger of a syringe.

A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.