A sub-assembly of a medicament delivery device is presented, where the sub-assembly includes a plunger rod that is biased, a main body arranged on the plunger rod, and a coupling member movable relative to the main body, where the main body includes a first locking element, the coupling member includes a second locking element, and where the first locking element and the second locking element are configured to be releasably engaged with each other such that the coupling member is prevented from moving relative to the main body.

Fluid connector systems including first and second valve assemblies couplable together to form a fluid pathway therethrough, and can resist fluid flow through the connector system when the valve assemblies are separated from each other, the first valve assembly including a compressible valve within a cavity and configured to surround a post forming a fluid passage, the compressible valve can resist fluid flow through the post in a first position and to reduce the resistance to fluid flow through the post in a second position, and the second valve assembly including a valve plug positioned within a bore and configured to obstruct a fluid passage, such that when the valve assemblies are coupled together the compressible valve is moved toward the second position and the post extends through the compressible valve and the valve plug to form the fluid pathway through the connector system.

A method of generating a customized headgear that includes a plurality of physical features and being usable with a mask component that supplies a flow of breathing gas to the patient's airways. The method includes receiving one or more parameters pertaining to the patient's head, subjecting at least some of the parameters to one or more algorithms to determine at least one of a length of a physical feature of the plurality of physical features and an angle between a pair of physical features of the plurality of physical features, generating an outline of at least a portion of a body which, when formed, is usable to assemble therefrom at least a portion of the headgear, and outputting a pattern usable to enable the formation of the at least portion of the body from at least a first sheet of at least a first material.

A method of adapting an auto injector configured to actuate a prefilled syringe, the auto injector having a biasing member having a spring constant, the prefilled syringe being filled with a volume of therapeutic fluid, the prefilled syringe including a barrel, stopper, and a needle, the stopper having a path of travel, the biasing member arranged to move the stopper along the path of travel. An auto injector having an injection spring adapted to an aged prefilled syringe.

A system is provided for generating a custom article to fit a target surface. During operation, the system compares an input dataset with a number of cut template cut meshes. A respective cut template cut mesh includes one or more cutting paths that correspond to a boundary of the mesh. Next, the system identifies a template cut mesh that produces a closest match with the input dataset, and applies global geometric transformations to the identified template cut mesh to warp the template cut mesh to conform to the input dataset. The system further refines and projects a set of boundary and landmark points from the template cut mesh to the input dataset to define cutting paths for the input dataset. Next, the system applies cutting paths to the input dataset to produce a cut-and-trimmed mesh.

Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.

A delivery device includes a base body having an outlet opening and a chamber for receiving a flowable substance to be administered. The base body, having first and second film portions attached to each other by a connection with a plurality of regions, being configured to discharge the substance through the outlet opening by compressing the chamber. The delivery device further includes a pouring adapter tightly connected to the outlet opening. The plurality of regions of the connection include a more resilient region and a less resilient region that are arranged between the chamber and the outlet opening. When the chamber is compressed to discharge the substance through the outlet opening, the less resilient region is configured to come undone and the more resilient region is configured to remain connected so that the substance can be discharged solely through the outlet opening and the pouring adapter by compressing the chamber.

A medical catheter includes a multi-lumen tube including a first lumen and a second lumen; an extension tube fixed to an end surface in a longitudinal direction of the multi-lumen tube, extending from the end surface along the longitudinal direction, and including a third lumen communicating with the first lumen; and an outer wall portion extending from the multi-lumen tube along the extension tube and configured to cover a part of an outer surface of the extension tube, the outer wall portion including a pipeline formed to communicate with the second lumen and having a part of the outer surface in an inner surface of the pipeline.

A cannula includes a tubular body having an axial dimension through which a flow channel extends. The tubular body has a first end for insertion into a subject, and a second end configured to be held within a base of a medical device. The tubular body has a first length portion extending along the axial dimension from the first end toward the second end. A second length portion extends along the axial dimension from the first length portion toward the second end, and has an outer dimension that flares outward to be larger than the outer dimension of the first length portion. The second length portion also has a tubing wall thickness that is greater than the tubing wall thickness of the first length portion.

Method and device for controlling the quantity of liquid contained in a cartridge for an aerosol generating device, wherein the cartridge has a container and a liquid contained in the container and wherein, according to which is measured the quantity of liquid contained in the cartridge; and compared the quantity of liquid with a reference quantity of liquid.