The present disclosure provides a metered dose inhaler (MDI) comprising an API formulation suitable for administration to a patient in need thereof by inhalation, as well as methods and uses of the MDI.

The present disclosure describes a personal vaporizer which can detect whether or not a cartridge of the personal vaporizer has been breached. The cartridge includes a conductive shell. The conductive shell can include two or more conductors which are electrically isolated from each-other. Prior to operation, the personal vaporizer can use the two or more conductors to assess whether or not an outer shell of the cartridge has been breached. In some implementations, if it is determined that the cartridge has been breached, the personal vaporizer can shut down, or otherwise fail to operate normally.

A method and a device for activating a function of a device, preferably of a medical device. The method includes the steps of: detecting an actual state of the device using a camera, preferably an AR device, which is preferably AR glasses; comparing the actual state of the device with a desired state of the device using a CPU connected to the camera; transmitting, on the basis of the comparison, a command for starting the function of the device or a function test, preferably a function test, from the CPU to the device; and activating the function or the function test of the device on the basis of this command.

Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

A biocontainment assembly for use with a patient suspected of having or diagnosed with a transmissible disease(s) capable of respiratory, airborne, contact, or droplet transmission includes a housing configured to be positioned over and at least partially enclose a head, neck, and/or torso of the patient. A sidewall of the housing includes an open portion contiguous with an at least partially pen bottom portion of the housing, sized to fit over at least a portion of the head, neck, and/or a torso of the patient. The housing also includes an airflow opening for evacuating fluid from an interior defined by the housing. The assembly also includes a drape configured to extend across the open portion of the sidewall having a first portion removably connected to the housing and an opposing second portion configured to be draped over the torso, abdomen, waist, and/or legs of the patient.

Methods and systems are provided for aerosolization of individual building blocks of medical microrobots and subsequent in situ assembly into microrobots capable of medical intervention deep within lung tissues of a subject. The methods and systems of the disclosure may allow for microrobot-based therapy of pulmonary diseases that have previously been difficult to effectively treat using conventional therapeutic approaches.

Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor.

A method for analysing a device for spraying a pharmaceutical fluid product including the following steps: providing a spray head of a device for spraying a pharmaceutical fluid product, the spray head having a spray orifice; providing a receiving surface having a plurality of discrete contact zones separated by voids, the contact zones capable of being coated with a heat sensitive material, bringing the receiving surface to a temperature T2, passing a flow of compressed gas through the spray orifice, the flow of compressed gas at a temperature T1 which differs from T2, sending the flow of compressed gas at temperature T1 onto the receiving surface at temperature T2, visualising the impact zone for the flow of compressed gas on the receiving surface, and analysing the visualisation of the impact zone in order to determine whether the spray head complies with predetermined specifications.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on dimensions and a distensibility of a non-occluded portion of the patient line. If the change in pressure, the incremental volume, properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, a location of the occlusion can be inferred. An occlusion type can be inferred based on the location of the occlusion.

An insulin pump data acquisition device & system including: an insulin pump data acquisition device for use with an insulin pump, the data acquisition device including a holster having a wall defining an interior volume and an exterior volume, the exterior volume being sized to removably secure the insulin pump; an environmental sensor operable to generate environmental data in response to environmental conditions; memory operably connected to the environmental sensor, the memory being operable to store the environmental data; a controller operably connected to the environmental sensor and the memory, the controller being operable to control reading of the environmental data from the environmental sensor and writing of the environmental data to the memory; and a battery operably connected to power the environmental sensor, the memory, and the controller. The environmental sensor, the memory, the controller, and the battery are disposed within the interior volume.