Apparatuses, systems, and methods are provided for securing an intra-osseous device within a safety device to prevent stick injuries and to guide the removal of the intra-osseous device from the bone of a patient. A body of the safety device has a cavity that receives the intra-osseous device, and the cavity guides the removal of the intra-osseous device along a straight line to prevent injury during removal. The intra-osseous device is drawn past a lock feature that secures the intra-osseous device within the body such that a needle of the intra-osseous device is contained within a cavity of the body and cannot injure the patient, staff members, etc.

A dual therapy device for delivering reduced pressure therapy and regenerative therapy to a degenerated vertebral disc and a method of using the same is disclosed herein. The dual therapy device is preferably comprised of a cannulated trocar for accessing a disc space, a probe that coils within said disc space and a cannulated and fenestrated catheter that also coils within the disc space, adjacent to the probe. The catheter is useful for applying reduced or negative pressure therapy to the entire or substantially entire disc space and, upon completion of said therapy, delivering regenerative therapy to the disc space in the form of a biological material. Nonetheless, it is also contemplated that the catheter may be eliminated, and the dual therapies delivered via a cannulated and fenestrated probe.

Apparatus and methods are provided to penetrate a bone and associated bone marrow using a powered driver. The powered driver is operable to insert an intraosseous device into a bone and associated bone marrow. The powered driver may include a housing having a distal end and a proximal end; a drive shaft having a first end disposed within the housing; a motor disposed within the housing and rotatably engaged with the drive shaft; a power supply to supply power to the motor; and a trigger assembly to activate the motor to rotate the drive shaft. A light may be connected to the power supply and operable to illuminate an insertion site for the intraosseous device.

A method of treating a bone defect is provided. The method comprises administering to the bone defect an amount of about 0.1 g to about 800 g of growth differentiation factor 5 (GDF-5) over a period of at least three days. An implantable matrix for treating a bone defect is also provided.

An apparatus and method for external anteversion correction of an intact bone may include a first arcuate segment, a second arcuate segment rotatably coupled to the first arcuate segment, a first pin extending from the first arcuate segment to a proximal segment of the intact bone, a second pin extending from the second arcuate segment to a distal segment of the intact bone, and a control mechanism attached to the first and second arcuate segments. The control mechanism may rotate the first arcuate segment relative to the second arcuate segment to exert torsional force on the intact bone between the proximal and distal segments of the intact bone, thereby externally reducing anteversion of the intact bone.

A penetrator assembly for penetrating a bone and associated bone marrow is provided. The penetrator assembly may include a first connector having a first end and a second end; an outer penetrator extending from the second end of the first connector; the outer penetrator comprising a longitudinal passageway and a first tip; a second connector having a first end and a second end; and an inner penetrator extending from the second end of the second connector, the inner penetrator comprising a second tip. The first connector may be configured to engage the second connector, and the inner penetrator may be disposed in the longitudinal passageway of the outer penetrator when the first connector is engaged with the second connector.

The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. An inner shaft having a distal end is slidable between a first position in which the distal end of the inner shaft is disposed in the barrel and a second position in which the distal end of the inner shaft extends past an opening in the end of the barrel. A tip containing a medicament is disposed about the opening of the elongated barrel. The tip includes at least one aperture for dispensing the medicament. One can inject the medicament from the tip into a bone fracture or degenerative bone tissue during surgery by actuating the trigger of the bioinjection device. A configurable tip may be employed to control the amount and direction of dispersion of such medicament.

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula.

An apparatus and method for penetrating bone marrow is provided. The apparatus may include a housing such as a handheld body, a penetrator assembly, a s connector that releasably attaches the penetrator assembly to a drill shaft, a gear mechanism, a motor and a power supply and associated circuitry operable to power the motor. The penetrator assembly may include a removable inner trocar and an outer penetrator or needle. It may also include a grooved trocar that allows bone chips to be expelled as the apparatus is inserted into bone marrow. Various connectors are provided to attach the penetrator assembly to the drill shaft.

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula.