An intraosseous access system can include a needle that defines a lumen and a longitudinal axis about which the needle can be rotated during an insertion event. The needle can include a proximal end that remains at an exterior of a patient during use, a distal end that can be inserted through the skin of the patient into contact with a bone of the patient, and a distal tip at a distalmost point of the distal end of the needle that is positioned at the longitudinal axis of the needle. The system can further include an obturator sized to be received within the lumen of the needle that can inhibit material from entering the needle as the system is inserted into the bone.

An example system includes a fluid delivery device configured to deliver gas nanobubbles to a target site of a patient from a solution comprising a fluid, supersaturated with a. gas, wherein the fluid delivery' device defines a flow channel configured to flow the solution through the flow channel such that the gas in the supersaturated fluid forms gas nanobubbles as the solution flows through the flow channel towards the target site, and wherein the gas nanobubbles remain in the fluid at least until delivery' to the target site.

A removable second stage biocompatible substrate filter including biocompatible implant material configured to trap second stage operative particulate matter, wherein the removable second stage biocompatible substrate filter is configured to combine with first stage operative particulate matter captured from irrigation fluid by a first stage filter, defining a combined product and the removable second stage biocompatible substrate filter is configured to be removable from a filter device container.

Systems, methods, and apparatuses are provided for delivering reduced pressure to a subcutaneous tissue site, such as a bone tissue site. In one instance, a manifold for providing reduced pressure to a subcutaneous tissue includes a longitudinal manifold body formed with at least one purging lumen and a reduced-pressure lumen. The manifold further includes a plurality of manifolding surface features or slits formed on the second, tissue-facing side of the longitudinal manifold body and a plurality of apertures formed in the longitudinal manifold body on the second, tissue-facing side. The plurality of apertures fluidly couple the reduced-pressure lumen and the manifolding surface features or slits. The manifold further includes an end cap fluidly coupling the reduced-pressure lumen and the at least one purging lumen. Other systems, apparatuses, and methods are presented.

A method of monitoring a bone fracture in an individual. The method comprises the steps of: measuring a first parameter indicative of the load on said bone fracture; measuring a second parameter indicative of the activity level of said individual; obtaining a plurality of values for said first and second parameters; correlating said values to determine a measure of bone fracture condition; monitoring a change in said correlation over time; and determining a measure of the change in bone fracture condition over time. A bone fixation system implements this method of monitoring a bone fracture in an individual. The method and system provide a more accurate and reliable measure of bone fracture condition and of the progression of healing of the bone fracture.

A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.

An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.

A device for straightening and stabilizing the vertebral column, particularly for stabilizing broken vertebrae, includes a supporting implant which is plastically expandable by internal pressure. The supporting implant can be placed into the interior of a vertebral body which has been fractured under compression or between adjacent vertebral bodies. A pressure balloon to which pressure fluid can be admitted may be arranged in the interior of the supporting implant for producing the internal pressure.

An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.