Method for targeted application of active agents to a target surface including: creating a digital geometric representation of the target surface; providing an array of applicators; selecting an applicator from the array of applicators based on the target surface; disposing the active agent on the applicator surface of the applicator; disposing the applicator on the target surface so that the active agent is in contact with the target surface; and removing the applicator from the target surface while leaving at least some of the active agent in contact with the target surface.

Method of defining at least one treatment area including receiving a first set of data from a digital geometric representation of a target area; receiving a second set of data representing at least a portion of an applicator designed to contact the target area; digitally overlying the second set of data over the first set of data to generate a first digital overlay; digitally defining a treatment area on the first digital overlay surrounding the condition; generating a third set of data representing a portion of the applicator and the treatment area; digitally overlying the third set of data over the first set of data to generate a second digital overlay representing coverage of a condition by the treatment area; and generating a first electronic image that includes a visual depiction of the second digital overlay.

The present disclosure provides for a microneedle array. The microneedle array is useable for delivering an active agent to a subject. The microneedle array includes a base having microneedles disposed thereon, wherein each of the microneedles is formed of (i) a swellable and water-insoluble matrix comprising a crosslinked polymer or (ii) a water-soluble matrix comprising a water-soluble polymer; and a conductive polymer incorporated in the swellable and water-insoluble matrix or the water-soluble matrix. A device configured to deliver an active agent and a method of delivering an active agent through the device, wherein the device includes the microneedle array, are provided herein. A method of producing the microneedle array is also disclosed herein.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

The present disclosure is directed to a holder. The holder includes a package including a containment portion and a separable portion, wherein the containment portion is separated from the separable portion by perforations, and a sheet within the package, the sheet including a first surface and a second surface, the second surface opposed to the first surface, the first surface operably attached to the separable portion, the sheet configured to extend a distance along an interior of the containment portion, wherein at least a portion of the first surface of the sheet contacts the interior surface of the containment portion, and wherein a liquid composition contacts a second surface of the sheet.

According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.

A hand-held device for local piercing of skin includes: a housing; a drive unit within the housing adapted to provide a driving force; piercing means within the housing having at least one piercing needle disposed on a needle carrier; and coupling means within the housing and connecting the drive unit to the piercing means such that the driving force is transmissible to the piercing means to repeatedly move the needle carrier with the at least one piercing needle between a forward and a rearward position during operation. A lever mechanism receives a drive stroke provided by the drive device via an input of the lever mechanism on the drive side when the driving force is transmitted, to convert the drive stroke into a working stroke which is different from the drive stroke and to output the working stroke to the piercing device via an output of the lever mechanism.

Module for housing electronic and electromechanical medical equipment including a portable digital camera and processing circuitry with machine vision and machine learning software for automatically documenting healthcare events and healthcare equipment operations in the electronic health record.

Module for housing electronic and electromechanical medical equipment including a portable digital camera and processing circuitry with machine vision and machine learning software for automatically documenting healthcare events and healthcare equipment operations in the electronic health record.

Methods, systems, and devices are provided for generating a mist. In one embodiment, a fluid delivery device is provided that includes a housing, a fluid vaporizer disposed within the housing and configured to receive fluid and to produce an aerosol mist of liquid particles from the fluid, and a pump configured to accelerate the aerosol mist produced by the fluid vaporizer. Methods are provided for producing a mist, and the methods can include delivering a fluid to a fluid vaporizer that generates a first mist. The fluid vaporizer delivers the mist to a pump that generates a second mist from the first mist.