Persons with sleep disordered breathing (SDB) may, or may not, recognize that they have symptoms of SDB, and/or that they may be at-risk of, or suffering certain health problems associated with SDB, including death. The disclosed Energy Conversion Monitor (ECM) sensor, when embodied, for example, in a wearable upper-armband format, has been demonstrated to be more sensitive and responsive than pulse oximetry monitoring of blood oxygen saturation as an indication of hypoxic stress induced by SDB, and is compatible with: (1) inclusion in sleep laboratory polysomnograph (PSG) testing instrumentation, (2) home-based diagnostic testing for SDB, (3) control of home-use airway therapy devices, (4) continuous remote surveillance and refinement of airway therapy, and (5) spot-check and continuous surveillance of sleep quality in the general population. The disclosed ECM also provides new measurements of physiologic stress during and following exercise. When applied during initial care of premature newborn infants, it offers improved therapeutic guidance during their transition from their limited in utero oxygen supply conditions, to the increased oxygen availability from breathing air. When applied during resuscitation of persons suffering from hypoxia and during reperfusion of ischemic tissue, such as during treatment of ischemic stroke, or ischemic heart attack, the ECM sensor can provide objective guidance regarding the safe and effective resupply of oxygen to the hypoxia-adapted tissue to help reduce or prevent microvascular occlusion and cellular injury. As a continuously worn physiologic surveillance monitor, the ECM offers the potential of early detection of sepsis. With the elderly and infirm, it offers a convenient and comfortable means of continuously assessing variations in status while awake and asleep.

According to some embodiments, a skin treatment assembly comprises a tip comprising a proximal end and a distal end, a container configured to secure to the tip along the proximal end of the tip, wherein the container is configured to contain a liquid, and a porous member configured to extend at least partially within an interior of the container such that it contact a liquid contained within the container, wherein the porous member is configured to extend at least partially within an interior of the tip and is configured to facilitate the transfer of liquid from the container to the distal end of the tip.

A microneedle chip and manufacturing method. The method comprises injecting, into a female mold, a fluid needle liquid, wherein forming cavities matching the shapes of needles of a microneedle chip are provided at the female mold and form a cavity array, injection inlets are provided at a surface of one side of the female mold, and air ejection openings are provided at a surface of another side of the female mold to form an air ejection surface; covering the air ejection surface of the female mold using a breathable film, and during injection, passing a gas through the breathable film so as to retain the liquid inside the forming cavities; curing the fluid needle liquid to form the microneedle chip, and demolding to obtain the same. By employing the air ejection openings and the breathable film, a liquid is retained while ejecting a gas, providing a favorable micro-injection effect.

The present invention relates to a member (14, 24, 26) of a patient interface (10) for providing a flow of breathable gas to a self-ventilating patient (12). The member (14, 24, 26) comprises a wear-out indicator (32) for indicating a wear-out of the member (14, 24, 26) to the patient (12). The wear-out indicator (32) comprises an elastic structure (34) that appears in a first colour in an unstressed condition and is configured to reversibly change its apparent colour when being stretched and returned to its unstressed condition again. The elastic structure (34) is configured to indicate a wear-out of the member (14, 24, 26) by appearing in a second colour in its unstressed condition when the structure (34) has lost at least a part of its elasticity, wherein the second colour is different from the first colour.

A liquid dispensing applicator may include a liquid source for housing a liquid. An absorbent member may be adjacent to a proximal end of the liquid source, and may be configured to deliver the liquid to an external surface. An attachment member may secure the absorbent member to the liquid source, and may include a through passage to allow the liquid to flow from the liquid source into the absorbent member. A rigid member may extend outwardly from the attachment member into the absorbent member. A shield member may be positioned adjacent to the attachment member and may extend from the attachment member so as to be positioned within the absorbent member. A capillary tube may be configured to provide fluid communication between the liquid source and the liquid dispenser upon application of pressure to the liquid source.

Disclosed herein are several embodiments of a reduced pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters. Certain embodiments are directed to connectors used to connect fluid passage tube used in transmitting negative pressure to a fabric channel used in a suction adapter.

A hand-held dispenser to dispense fluid includes a casing to fit into a hand of a user, a nozzle in the casing to dispense a mist, a fluid reservoir contained in the casing to hold a fluid to be turned into the mist, a filament extension atomizer contained in the casing to generate the mist, an air source contained in the casing to provide air flow to direct the mist to the nozzle, a motor contained in the casing to operate the filament extension atomizer, an actuator positioned on the casing to activate the dispenser, a control circuit contained in the casing to receive a signal from the actuator and to send a signal to the motor to cause the motor to actuate, and a power source contained in the casing to provide power to the motor upon receive a signal from the control circuit.

In an exemplary embodiment, a drug delivery device is configured for Body Channel Communication (BCC). The drug delivery device may include a conductive element embedded in an adhesive patch that secures the drug delivery device to the user. This conductive element acts as a coupler to the body of the user. Another conductive element may also be provided at a face of the housing. This conductive element acts as the other end of the coupler formed with the conductive coil in the adhesive patch. The conductive coil in the adhesive patch conforms well to the user's skin surface and thus facilitates a good quality coupling with the user.

An automatic tattoo apparatus can be used to robotically apply tattoos. A customer can shop on an online tattoo marketplace to select designs created by various artists located anywhere. The online tattoo marketplace can process and manage payments, artist and/or customer profiles, bookings, tattoo design uploads, browsing and design selection, design changes, and/or perform other actions. The automatic tattoo device can apply tattoos precisely, quickly, and may with reduced pain. The tattoo apparatus can apply a wide range of different types of tattoos, including but not limited to micro tattoos, dotwork, blackwork tattoos, realism tattoos, fine-line tattoos, etc.

A pharmaceutical composition for treating infertility in a female subject substantially consists of local anesthetic of amide type such as lidocaine, human albumin, viscosity controlling agent selected from recombinant hyaluronic acid and combination of recombinant hyaluronic acid and water-soluble cellulose ether, optionally citrate, glucose, and/or amino acid, water optionally comprising one or more ions selected from the group consisting of sodium, potassium, magnesium, calcium, acetate, chloride, sulfate. Also disclosed is a method of treating infertility by administration of the composition to a female subject in need thereof.