Devices and methods can be used to apply an adhesion promoter, for example, ozone, over the surface of the biological tissues, before and/or concurrently with the application of the cosmetics to improve the durability and/or appearance of the cosmetics on the biological tissues. The devices can include a recirculation system and/or a filter system to reduce the likelihood of the chemical being released into the atmosphere and/or to increase oxidation of the chemical generated by the device after use of the device.

A microneedle set including a microneedle injection device that introduces a liquid to a skin of a body part, and a piercing assisting tool fixable to the body part. The microneedle injection device includes a hollow needle shaped body having a projection in an end portion thereof and a through hole connected to the projection such that the liquid passes through the through hole and is released from a tip portion of the projection, and a supply device that supplies the liquid to the hollow needle shaped body. The piercing assisting tool includes a fixing part which has an aperture formed therein and fixes a position of the aperture on the body part, and a cover connected to a peripheral portion of the aperture such that the aperture is opened or closed by the cover.

An apparatus for applying negative pressure to a tissue site of a patient may include a tissue interface, a cover, an aperture in the cover, and a sealing member. The tissue interface may have an anatomical shape configured to cover the tissue site. The cover may be configured to cover the tissue interface. The aperture in the cover may be fluidly coupled to the tissue interface. The sealing member may be configured to seal the cover to the patient, wherein the cover and the sealing member are configured to cooperate to form a sealed chamber containing the tissue interface. The tissue interface may be coupled to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site. The source of negative pressure may be coupled to the cover of the apparatus.

An apparatus for applying negative pressure to a tissue site proximate a patient's foot may include a tissue interface, a sole, a toe box, a cover, and an interface. The tissue interface may be configured to be circumferentially disposed around the tissue site. The sole may be configured to support the tissue interface. The toe box may be coupled to the sole. The cover may be configured to be coupled to the leg and to the sole to cover the tissue interface. The cover and the sole may form a chamber containing the tissue interface and may seal the tissue interface within the chamber. The interface may be configured to fluidly couple the tissue interface to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site.

A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.

A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.

A bi-directional cannula for perfusing blood in two directions. The cannula has a distal opening in fluid communication with a cannula first lumen. The cannula has a secondary opening proximal of the distal opening, and may include a movable tubular extension selectively extendable from the cannula via the secondary opening. The tubular extension may be in fluid connection with the cannula first lumen and/or a cannula second lumen. The tubular extension may have distal and/or side openings, with the openings providing antegrade fluid perfusion. The cannula second lumen may be separate from the first lumen, so that perfusion can be selectively provided to just the cannula distal opening, just the secondary opening/tubular extension, or simultaneously to both the distal opening and secondary opening/tubular extension.

A device, system and method for increasing air intake by a subject is described. The device includes a vibration motor and a control unit for controlling vibrational motion output by the vibration motor. The methods include positioning the vibration motor on one or more limbs of a subject, and stimulating nerves in the limbs via the generated vibrational motion, whereby the stimulated nerve signals the brain to increase breathing rate or air intake by the subject. Accordingly, embodiments of the device activate nerve fibers that carry kinesthetic cues from the limbs in a pattern that simulates normal limb motion, and thus triggers inherent reflexes that increase ventilation in response to such motion.

A limb-stabilisation apparatus (100) comprises a limb-receiving container (110) arranged to receive a portion of the limb (5) and to collect blood exited from the limb; and a blood recirculation system (120) configured to recirculate blood from the limb-receiving container (110) to one or more regions of the limb. Advantageously, the limb-stabilisation apparatus (100) may further comprise or may be associated with a limb-compressing apparatus (210) configured to reduce, restrict or prevent blood flow in the region of the limb-compressing apparatus.

A device, system and method for increasing air intake by a subject is described. The device includes a vibration motor and a control unit for controlling vibrational motion output by the vibration motor. The methods include positioning the vibration motor on one or more limbs of a subject, and stimulating nerves in the limbs via the generated vibrational motion, whereby the stimulated nerve signals the brain to increase breathing rate or air intake by the subject. Accordingly, embodiments of the device activate nerve fibers that carry kinesthetic cues from the limbs in a pattern that simulates normal limb motion, and thus triggers inherent reflexes that increase ventilation in response to such motion.