A device for increasing the well-being of living beings, including a brain stimulator for generating a stimulation signal in the infrasonic range, the brain stimulator being used to stimulate the brain of the living being. A massager is provided for generating a massage signal, by means of which body parts of the living being can be massaged.

Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

The present disclosure provides systems and methods for nitric oxide (NO) generation and/or delivery. In some aspects, a nitric oxide generation system comprises a plasma chamber configured to ionize a reactant gas including nitrogen and oxygen to form a product gas that includes NO, a scrubber downstream from the plasma chamber and having a volume at least partially containing NO.sub.2 scrubbing material, and a flow controller downstream of the scrubber configured to control the flow of product gas from the scrubber to a delivery device. A pump is configured to convey product gas from the plasma chamber into the scrubber and is configured to pressurize the product gas in the scrubber when the flow controller is positioned to restrict the flow of product gas from the scrubber. The pressurized product gas accumulates within the scrubber and is at least partially scrubbed of NO.sub.2 prior to passage through the flow controller.

Systems and methods for reducing vibrations perceived by a human due to an artificial heart valve include a vest that is wearable around a torso of the human, a plurality of sensors mounted to the vest, a plurality of vibration-generating actuators mounted to the vest, and a controller. The plurality of sensors detects vibrations in the human generated by the artificial heart valve. The controller is operable to receive signals representing the detected vibrations from the plurality of sensors, and is operable to produce anti-vibration signals that substantially attenuate the detected vibrations. A first sensor of the plurality of sensors is located near a first vibration-generating actuator of the plurality of vibration-generating actuators to form a sensor/actuator set. In the sensor/actuator set, the anti-vibration signals generated by the controller for the first vibration-generating actuator correspond to the vibrations detected by the first sensor.

Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

Respiratory distress apparatuses, systems and methods are described. An example respiratory distress management device includes a housing, and further has a mechanical ventilation apparatus and a controller within the housing. The controller may include a processor and a memory. The controller may be configured to determine whether, at a particular time, a fault mode condition exists. If a fault mode condition is determined not to exist, then the controller may be configured to enable control of the mechanical ventilation apparatus of the respiratory distress management device by a source in delivering mechanical ventilation to a patient, via signals received by the controller from the source. If a fault mode condition is determined to exist, then the controller may be configured to control the mechanical ventilation apparatus of the respiratory distress management device in delivering mechanical ventilation to the patient.

Methods and apparatus for administering oxygen therapy, and particularly high-flow oxygen therapy is disclosed herein. A respiratory monitoring system may non-invasively determine average peak inspiratory flow rate of a patient based on biofeedback response received from the patient. Medical air, oxygen, or a combination of both may be delivered to the patient at a flow rate equal to greater than the determined average peak inspiratory flow rate of the patient to meet or exceed inspiratory demand of the patient. Fraction of oxygen inspired by the patient may be determined based on the average peak inspiratory flow rate and may be adjusted through high-flow oxygen therapy meeting inspiratory demand to prevent entrainment of ambient air or through low-flow oxygen therapy by accounting for entrainment of ambient air based on the average peak inspiratory flow rate to address medical needs of the patient.

Systems and methods for reducing vibrations perceived by a human due to an artificial heart valve include a vest that is wearable around a torso of the human, a plurality of sensors mounted to the vest, a plurality of vibration-generating actuators mounted to the vest, and a controller. The plurality of sensors detects vibrations in the human generated by the artificial heart valve. The controller is operable to receive signals representing the detected vibrations from the plurality of sensors, and is operable to produce anti-vibration signals that substantially attenuate the detected vibrations. A first sensor of the plurality of sensors is located near a first vibration-generating actuator of the plurality of vibration-generating actuators to form a sensor/actuator set. In the sensor/actuator set, the anti-vibration signals generated by the controller for the first vibration-generating actuator correspond to the vibrations detected by the first sensor.

Sleep trainer (1) comprising a band (2) with two electrodes (21), (22) for carrying out an impedance measurement and a monitor (3) for receiving a measurement signal. The band has a band pocket (23). An electrical connection is obtained by inserting the monitor (3) into the band pocket (23). Band contact points ((210),220) are provided inside the band pocket (23). Monitor contact points (31), (32) are provided at an external surface of the monitor housing (30). The monitor contact points are flat and hardly protrude above the monitor housing. The band pocket (23) prevents a lateral movement of the monitor and a band pocket wall (231) exerts a pressing force to keep the monitor contact points (31), (32) in an abutting engagement with the band contact points (210), (220). Advantageously, the sleep trainer provides a high level of wearing comfort which contributes to a sleep disorder treatment compliance.