Systems and methods to mitigate negative effects of a drug in a treatment of a mental health condition include administering a drug to a subject in a therapy session; determining effects of the drug, the effects being counterproductive to the therapy session; and providing tactile stimulation to a subject with a stimulation device that generates transcutaneous vibratory output to be applied to a portion of a body of the subject during the therapy session, wherein the transcutaneous vibratory output is selected to reduce the counterproductive effects of the drug.

An aerosol-generating system has a biosensor configured to detect a biological characteristic of the user. A controller provides health data based on the at least one biological characteristic detected by the biosensor. The health data may be provided to the user, used to modify an aerosol delivery profile of an aerosolizer, stored for later use, or may be communicated to other devices.

An aerosol-generating system has a biosensor configured to detect a biological characteristic of the user. A controller provides health data based on the at least one biological characteristic detected by the biosensor. The health data may be provided to the user, used to modify an aerosol delivery profile of an aerosolizer, stored for later use, or may be communicated to other devices.

An apparatus and method for assessing vascular compliance in subjects with multiple sclerosis using sequential gas delivery is provided. The apparatus includes a gas delivery device and a processor. The processor controls the gas delivery device to deliver a first and second gas during a single inspiration. The first gas contains a mixture of oxygen and carbon dioxide necessary to target an end-tidal concentration of the two gases. The second gas includes a concentration of carbon dioxide equal to the target end-tidal concentration of carbon dioxide.

An apparatus and method for assessing vascular compliance in subjects with multiple sclerosis using sequential gas delivery is provided. The apparatus includes a gas delivery device and a processor. The processor controls the gas delivery device to deliver a first and second gas during a single inspiration. The first gas contains a mixture of oxygen and carbon dioxide necessary to target an end-tidal concentration of the two gases. The second gas includes a concentration of carbon dioxide equal to the target end-tidal concentration of carbon dioxide.

A treatment device configured noninvasively to treat neurological conditions and/or neuropsychiatric conditions, designed to modulate autonomic nervous system through biofeedback configured to change brain network. The treatment device comprising: physiological sensor, storage piling psychological data and operating controller to effectively provide at least one of biofeedback and tactile stimulation to the individual to curtail neurological and/or neuropsychiatric events.

A method for treatment of a brain and/or spinal cord includes inserting a flexible catheter into a cerebrospinal fluid space, the flexible catheter including two lumens adapted to allow a fluid to circulate therein in a closed loop within the flexible catheter and the flexible catheter being adapted to be connected to a device for cooling and circulating the fluid. The cerebrospinal fluid in the cerebrospinal fluid space is cooled with the flexible catheter to enable selective central nervous system cooling. The functional status of the brain and/or spinal cord is monitored, and the treatment of the brain and/or spinal cord is modified to adjust for any change in the functional status of the brain and/or spinal cord.

A system for regeneration of at least one severed nerve conduit, configured for use in a living human or animal body. The at least one nerve conduit comprises at least one motor nerve conduction part and at least one sensory nerve conduction part. The system comprises: a motion device, configured for moving a body part of the human or animal body, for containing at least one skeletal muscle that is otherwise innervatable with the at least one severed nerve conduit, a signal generator, which generates a first electrical stimulation signal and a second electrical stimulation signal, including an evaluation and control, which controls the motion device and the signal generator to be coordinated with one another.

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

A system for altering the brain state of a user is disclosed. The system may receive, from at least one sensor, data associated with one or more biometric markers of the user, and determine a brain state of the user based on the data associated with the one or more biometric markers of the user. The system may determine a desired altered cognitive/emotional state of the user (or a desired brainwave state), and cause one or more emitters to apply a stimulus or stimuli to the user.