In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

Disclosed is a bioimpedance measurement system: A stabilized high frequency current generator is connected to PadSet electrodes via a Patient Cable. Electrodes are connected to an adaptive circuit that conditions the resulting voltage signal and converts it to digital form. Firmware performs signal acquisition and relays data to the device.

A blood glucose control system according to an embodiment of the present invention includes a continuous blood glucose meter configured to continuously measuring blood glucose of a patient, a bio-signal sensor configured to acquire a bio-signal of the patient, a lifelog data collector configured to collect lifelog data of the patient, an insulin injection controller configured to determine an insulin injection amount and an injection rate based on one or more of blood glucose measurement information and blood glucose metabolism characteristic information received from the continuous blood glucose meter, the bio-signal acquired by the bio-signal sensor or a stress level of the patient indexed by the bio-signal, and the lifelog data collected by the lifelog data collector, and an insulin pump configured to inject insulin into a body of the patient according to the insulin injection amount and the injection rate determined by the insulin injection controller.

Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Non-pharmaceutical systems and methods of treating the symptoms of fibromyalgia are described. The method includes administering a therapeutically effective amount of a sensory stimulus to a person, wherein the sensory stimulus includes one or more visual stimuli and one or more auditory stimuli.

Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

An electronic device includes a user interface; a wireless communication circuit configured to communicate with an external electronic device; a processor; and a memory electrically connected to the processor. The memory stores instructions that, when executed by the processor, cause the processor to: identify a user input to start a meditation program via the user interface; start the meditation program in response to the identified user input; receive data related to a stress level of a user measured by the external electronic device during execution of the meditation program from the external electronic device via the wireless communication circuit; and display visual information on the user interface, wherein the visual information visually indicates a stress level change of the user resulting from the execution of the meditation program, based on at least a portion of the received data. In addition, various embodiments identified herein are realized.

An aerosol generating device includes: an output unit; a biometric information obtaining unit configured to obtain an image of a pupil of a user; a communication unit configured to transmit the image of the pupil of the user to a server and receive information about a recommended cartridge corresponding to the emotional state calculated by the server using a neural-network-based emotion calculation model and a neural-network-based cartridge recommendation model; and a controller configured to control the output unit to output the recommendation cartridge information.

An aerosol generating device includes: an output unit; a biometric information obtaining unit configured to obtain an image of a pupil of a user; a communication unit configured to transmit the image of the pupil of the user to a server and receive information about a recommended cartridge corresponding to the emotional state calculated by the server using a neural-network-based emotion calculation model and a neural-network-based cartridge recommendation model; and a controller configured to control the output unit to output the recommendation cartridge information.