Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.

A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a plasma separation device to separate a plasma component from blood flowing through the line, a factor separating device to separate a factor component which is a pathogenic factor from the plasma component, a detector to detect blood information relating to blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquire control parameters output from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.

Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a blood purification device to purify the blood flowing through the line, a supply device to supply dialysate or replacement fluid to the line, a detector to detect blood information relating to the blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquires control parameters outputted from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.

Detection of unintentional air leaks in a user interface (e.g., mask) of a respiratory therapy system (e.g., a positive air pressure device) is disclosed. One or more sensors (e.g., within a computing device, such as a smartphone) can be moved around relative to the user interface to determine a location and/or intensity of an air leak. The computing device can provide feedback regarding the location and/or intensity of the air leak to facilitate the user locating the air leak, and thus correcting the air leak. In some cases, augmented reality annotations can be overlaid on an image (e.g., live image) of the user wearing the user interface to identify the location of the air leak. The system can automatically detect the type of user interface being used and can provide tailored guidance for reducing the air leaks.

Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor.

Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor.

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

A system and method for providing sensory relief from distractibility, inattention, anxiety, fatigue, and/or sensory issues to a user in need. The user can be autistic/neurodiverse, or neurotypical. The system can be configured to obtain user sensory sensitivity data indicating a user's visual, sonic, or interoceptive, sensitivities; determine, using at least the user sensory sensitivity data, sensory thresholds specific to the user and mediation data corresponding to mediations specific to the user; store the sensory thresholds and mediation data; record, using one or more sensors, a sensory input stimulus to the user; compare the sensory input stimulus with the sensory thresholds; in response to comparing the sensory input stimulus with the sensory thresholds, determine, based at least on the mediation data, a mediation to be provided to the user, the mediation configured to provide the user relief from distractibility, inattention, anxiety, fatigue, or sensory issues.