Apparatus and methods provide compliance management tools such as for respiratory pressure therapy. In some versions, a respiratory pressure therapy system may include one or more processors, such as of a data server, configured to communicate with a computing device and/or a respiratory pressure therapy device. The respiratory pressure therapy device may be configured to deliver respiratory pressure therapy to a patient for a session. The computing device may be associated with the patient. The processor(s) may be further configured to compute a therapy quality indicator of the session from usage data relating to the session. The therapy quality indicator may be a number derived from contributions of a plurality of usage variables for the session in the usage data. The processor(s) may be further configured to present, such as by transmitting, the therapy quality indicator to the computing device. The therapy quality indicator may promote patient compliance.

In one embodiment, a method for accurate leak estimation in a flow generation system includes measuring a total flow through the flow generation system, measuring a pressure in in the primary flow circuit of the flow generation system, determining when the measured pressure is within a predetermined threshold of EPAP, and calculating an intentional leak flowrate and an unintentional leak flowrate based on the relationship Q.sub.FS(t)=Q.sub.IL(t)+Q.sub.UL(t) when the measured pressure is within the predetermined threshold. In another embodiment, a flow generation system includes in one embodiment an airflow generator connected in-line to a flow sensor, a pressure sensor and a patient interface connection by a first gas flow circuit, and a controller electrically coupled to the airflow generator, the flow sensor and the pressure sensor. The controller sends a control signal to the airflow generator based on a first flow value measured from the flow sensor and an unintentional leak flow value that is derived from a proportional relationship with an intentional leak flow value.

Method of treating an individual following a period of ischemia are provided. The methods include administering inhaled agents postconditioning to the individual and optionally simultaneously performing cardiopulmonary resuscitation. The inhaled agents include at least one noble gas.

A breathable gas supply regulation device of gas supplied by a respiratory assistance apparatus in breath assistance comprising a first input receiving a leakage signal produced by a detection member. The device regulates the supply of breathable gas to the patient in response to a received leakage signal, comprises a second input receiving a patient mouth movement measurement signal. The device comprises a processing unit provided for generating a synchronisation signal between the movement signal and the leakage signal. The processing unit generates a modification amount indicating the modification to be applied to the supply of breathable gas.

The invention comprises a method of operating a breathing apparatus comprising measuring a baseline breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, varying the flow rate provided by the breathing apparatus, measuring a current breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, comparing the baseline and current breath flow parameters, and altering operation of the breathing apparatus based on the comparison. The invention also comprises a breathing apparatus that implements the above method.

A system for conducting inhalation studies includes an inhalation exposure chamber and an aerosol delivery line connected to the inhalation exposure chamber. The aerosol delivery line is configured to produce a bi-directional and symmetrical presentation of aerosol to the inhalation exposure chamber. A laminar flow element is configured to create an ante-chamber where complete and turbulent mixing of the aerosol occurs. A radial exhaust and the laminar flow element enable laminar flow of the aerosol through the inhalation exposure chamber.

A water reservoir includes a water reservoir base configured to hold a volume of water to be used for humidification of pressurized breathable air, a water reservoir lid connected to the water reservoir base, and a compressible resilient portion configured to seal between the water reservoir base and the water reservoir lid. The base and the lid are movable relative to one another when connected whilst maintaining sealing therebetween due to the compressible resilient portion. A retainer is configured to secure the water reservoir to a water reservoir dock, and has a protrusion or recess to releasably engage one another when the water reservoir is received in the dock, with a reaction force to compression of the compressible resilient portion urging the protrusion and the recess into engagement with one another.

A water reservoir includes a water reservoir base configured to hold a volume of water to be used for humidification of pressurized breathable air, a water reservoir lid connected to the water reservoir base, and a compressible resilient portion configured to seal between the water reservoir base and the water reservoir lid. The base and the lid are movable relative to one another when connected whilst maintaining sealing therebetween due to the compressible resilient portion. A retainer is configured to secure the water reservoir to a water reservoir dock, and has a protrusion or recess to releasably engage one another when the water reservoir is received in the dock, with a reaction force to compression of the compressible resilient portion urging the protrusion and the recess into engagement with one another.

A respiratory flow limitation detection device, which can include an airway pressure treatment generator, determines a flow limitation measure based one or more shape indices for detecting partial obstruction and a measure of a patient's ventilation or respiratory duty cycle. The shape indices may be based on function(s) that ascertain the likelihood of the presence of M-shaped breathing patterns and/or chair-shaped breathing patterns. The measure of ventilation may be based on analysis of current and prior tidal volumes to detect a less than normal patient ventilation. The duty cycle measure may be a ratio of current and prior measures of inspiratory time to respiratory cycle time to detect an increase in the patient's inspiratory cycle time relative to the respiratory cycle time. A pressure setting based on the flow limitation may then be used to adjust the treatment pressure to ameliorate the patient's detected flow limitation condition.

A system and method configured to control pressure during enhanced cough flow of a subject are provided. A pressure regulator is operated such that during an individual exhalation of the subject, the pressure regulator is toggled between a first mode in which a subject interface is closed such that substantially no gas is communicated with the airway of the subject there through and a second mode in which the subject interface is opened to cause a series of exsufflation events for the individual exhalation of the subject. The pressure relief valve is associated with the subject interface and configured to open and release gas out of the subject interface, responsive to pressure within the subject interface exceeding a predetermined threshold value so as to maintain the pressure within the subject interface within a predetermined pressure range during the enhanced cough flow.