A ventilation apparatus has a breathing gas delivery system for delivering breathing gas to a user of the apparatus as ventilation therapy, with a controllable pressure and flow. The breathing pressure and flow are monitored to derive a respiration variability. A state of relaxation of the user is derived during provision of breathing assistance based on at least the respiration variability. Settings of the ventilation apparatus are then adapted dependence on the estimated state of relaxation for assisting the user in habituating to the breathing assistance, and hence habituating to breathing therapy.

Systems methods are described for modifying sleep patterns based on biofeedback. The method may include identifying a target sleep pattern from a plurality of candidate sleep patterns, receiving biofeedback information from a user, identifying a stimulus pattern based on the target sleep pattern and the biofeedback information, and providing at least one stimulus to the user based on the stimulus pattern.

A user interface of a respiratory therapy system includes a strap assembly, a frame, a connector, and a sensor. The strap assembly is positioned about a head of a user when the user wears the user interface. The frame is physically and electrically connected to the strap assembly, and defines an aperture. The connector has a first end portion and second end portion. The first end portion of the connector can be positioned within the aperture of the frame such that the connector is physically and electrically connected to the frame. The sensor is coupled to the strap assembly or the frame such that the sensor abuts a target area of the user when the user wears the user interface.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.

A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

The present invention relates to a method and a respiration device having a respiration unit for generating an airflow for the respiration and having a monitoring unit. The monitoring unit is used to detect a respiration parameter and to classify events in the respiration on the basis of monitoring of the respiration parameter. In this case, the monitoring unit is configured to carry out an event analysis to recognize an occurrence, which is characteristic for Cheyne-Stokes respiration, of chronologically successive events and for this purpose to ascertain the period length thereof and to compare them to one another and to register the presence of Cheyne-Stokes respiration when the compared period lengths each deviate by less than 40% from one another.

The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.

Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.

Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.