A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.

In a high voltage, variable frequency radiation generation system, a carrier signal supplied to a primary coil of a transformer is varied, e.g., turned ON and OFF at variable frequencies. The ON duration and/or the average amplitude of the carrier signal may also be varied. Moreover, the carrier signal may be modulated using an audio signal. The parameters to control the variation of the carrier can be provided as a recipe via a software application. A server can provide different types of apps providing different control features. The server may also collect user characteristic data and recipe usage data, and may facilitate exchange of these data and may recommend recipes based on a particular user characteristic.

In a high voltage, variable frequency radiation generation system, a carrier signal supplied to a primary coil of a transformer is varied, e.g., turned ON and OFF at variable frequencies. The ON duration and/or the average amplitude of the carrier signal may also be varied. Moreover, the carrier signal may be modulated using an audio signal. The parameters to control the variation of the carrier can be provided as a recipe via a software application. A server can provide different types of apps providing different control features. The server may also collect user characteristic data and recipe usage data, and may facilitate exchange of these data and may recommend recipes based on a particular user characteristic.

A method for killing or damaging cancerous cells in a living body comprising introducing glucose or other organic material as a biasing component into heating cancerous cells for purposes of destroying the cancerous cells with a second method of heating, such as by bombardment of energy from an external electromagnetic source, so as to raise the temperature of the tumor or cancerous cells to a degree that they are damaged or expire.

Improved hydrogel configurations for use with a TTField-generating system is disclosed. Also disclosed are kits containing the improved hydrogel configurations and methods of producing and using the improved hydrogel configurations.

A method and apparatus for treatment of cancer is provided. The method can include systemic administration of selective A3 adenosine receptor (A3AR) agonists like CI-IB-MECA (CF 101), LI-529, cordycepin or similar drugs in combination with application of pulsed Electric Field Stimulation (EFS) to the treatment area. A3AR agonists may be delivered in blend with allosteric enhancers of A3AR agonists potency like LUF6000 or other similar drugs. EFS is provided in three or more directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal several-fold stronger than the signal created by an agonist alone. The apparatus may be dedicated to one patient usage over long period of time—hours and days continuously or intermittently.

A method and apparatus for treatment of cancer is provided. The method can include systemic administration of selective A3 adenosine receptor (A3AR) agonists like CI-IB-MECA (CF 101), LI-529, cordycepin or similar drugs in combination with application of pulsed Electric Field Stimulation (EFS) to the treatment area. A3AR agonists may be delivered in blend with allosteric enhancers of A3AR agonists potency like LUF6000 or other similar drugs. EFS is provided in three or more directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal several-fold stronger than the signal created by an agonist alone. The apparatus may be dedicated to one patient usage over long period of time—hours and days continuously or intermittently.

When treating a subject using alternating electric fields (e.g., using TTFields to treat a tumor), some subjects experience an electrosensation effect when the alternating electric field switches direction. This application describes a variety of approaches for reducing or eliminating this electrosensation. More specifically, during the course of treatment using alternating electric fields, additional electrical signals that reduce the subject's sensation are applied during each of a plurality of time intervals, and these additional electrical signals interact with the relevant nerve cells to reduce the sensations.