Certain drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain first frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. Moreover, certain drugs and other molecules cannot ordinarily traverse cell membranes. However, when alternating electric fields at certain second frequencies are applied to the cells (e.g., 150 kHz for uterine sarcoma cells), the cell membranes become permeable to those molecules. To get a certain drug past both the BBB and the relevant cell membranes, the permeability of both of those barriers can be overcome by sequentially (or simultaneously) applying alternating electric fields at both the first frequency and the second frequency.

The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.

A body orifice remodeling device includes a cylindrical handpiece having a defined length which is adapted to be inserted into the body orifice and an elongated monopolar electrode mounted outside on the circumference of the cylindrical handpiece and extending substantially along the length of the handpiece. A source of radio frequency (RF) energy in the handpiece is configured to generate RF energy to the elongated monopolar electrode; and a source of electromagnetic stimulation energy (EMagS) in the handpiece is configured to generate (EMagS) energy.

Control systems and methods for delivery of energy that may include control algorithms that prevent energy delivery if a fault is detected and may provide energy delivery to produce a substantially constant temperature at a delivery site. In some embodiments, the control systems and methods may be used to control the delivery of energy, such as radiofrequency energy, to body tissue, such as lung tissue.

A device for radio frequency (RF) skin treatment of skin of a user is provided. The device comprises an active electrode and a return electrode. The device further comprises an RF generator arranged to supply RF energy to the user's skin via the active electrode and the return electrode. The return electrode has a planar skin contact surface extending in a main plane. The active electrode has a skin contact surface with a maximum dimension in a range from 100 μm to 500 μm, and a surface area of the planar skin contact surface of the return electrode is at least 5 times larger than a surface area of the skin contact surface of the active electrode. The skin contact surface of the active electrode is arranged in a position at a distance from the main plane, seen in a direction perpendicular to the main plane. The device may be advantageously used, for example, to control the dimensions and shape of a thermal lesion in the user's skin generated by the RF energy.

The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range T.sub.1 while another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T.sub.2.

A high-frequency energy transfer device includes a signal transfer part for transferring a signal to the skin through an electrode assembly, which comprises electrodes to which signals having at least one frequency according to at least one type are applied, and which function as multiple center shafts having one-side surfaces that cross each other and are to come into contact with the skin to be cared, and dielectric materials disposed at one side and the other side of each of the electrodes; and a housing forming a frame for receiving the signal transfer part.

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.

Applicators, systems, and methods for delivering electrical energy to a target treatment region with large area surface electrodes are disclosed. In one example, a system may include a housing, a pulse generator, and a treatment applicator coupled to the pulse generator and configured to deliver sub-microsecond high-voltage electric pulses from the pulse generator. The treatment applicator may include a first and second electrodes coupled to a substrate, where the first and second electrodes are configured to provide a uniform gap between edges of the first and second electrodes.